| Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora | |
Wang, Wei-Guang1,2; Li, Xiao-Nian1; Du, Xue1; Dong, Ke1; Zhao, Wei1; Wu, Hai-Yan1; Kong, Ling-Mei1; Li, Yan1 ; Pu, Jian-Xin1; Sun, Han-Dong1
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| 通讯作者 | Pu, JX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China,pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 2012-05-30 | |
| 发表期刊 | TETRAHEDRON LETTERS
 |
| ISSN | 0040-4039 |
| 卷号 | 53期号:22页码:2777-2781 |
| 摘要 | Two novel caged ent-kauranoids, neolaxiflorins D (1) and E (2), along with three other new ent-kauranoids, neolaxiflorins F-H (3-5), and a known one, eriocalyxin B (6), were obtained from lsodon eriocalyx var. laxiflora. Neolaxiflorin D (1) is the first 15,16-seco-16,17-dinor-ent-kaurane diterpenoid, and neolaxiflorin E (2) is the first 15,16-seco-17-homo-ent-kauranoid. The absolute configurations of ent-kauranoids 1 and 2 were determined by single-crystal X-ray diffraction analyses. Structural analysis of intermediate compounds 3-5 indicated that eriocalyxin B (6) is a biogenetic precursor of caged ent-kauranoids 1 and 2 as illustrated. The cytotoxic activity of the new compounds was evaluated by an MIT assay. (C) 2012 Elsevier Ltd. All rights reserved. |
| 关键词 | Caged Diterpenoid Ent-kaurane Isodon Eriocalyx Var. Laxiflora |
| 学科领域 | Chemistry |
| DOI | 10.1016/j.tetlet.2012.03.112 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000303953200027 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17609 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wei-Guang,Li, Xiao-Nian,Du, Xue,et al. Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora[J]. TETRAHEDRON LETTERS,2012,53(22):2777-2781. |
| APA | Wang, Wei-Guang.,Li, Xiao-Nian.,Du, Xue.,Dong, Ke.,Zhao, Wei.,...&Sun, Han-Dong.(2012).Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora.TETRAHEDRON LETTERS,53(22),2777-2781. |
| MLA | Wang, Wei-Guang,et al."Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora".TETRAHEDRON LETTERS 53.22(2012):2777-2781. |
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