Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora
Wang, Wei-Guang1,2; Li, Xiao-Nian1; Du, Xue1; Dong, Ke1; Zhao, Wei1; Wu, Hai-Yan1; Kong, Ling-Mei1; Li, Yan1; Pu, Jian-Xin1; Sun, Han-Dong1
2012-05-30
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号53期号:22页码:2777-2781
摘要Two novel caged ent-kauranoids, neolaxiflorins D (1) and E (2), along with three other new ent-kauranoids, neolaxiflorins F-H (3-5), and a known one, eriocalyxin B (6), were obtained from lsodon eriocalyx var. laxiflora. Neolaxiflorin D (1) is the first 15,16-seco-16,17-dinor-ent-kaurane diterpenoid, and neolaxiflorin E (2) is the first 15,16-seco-17-homo-ent-kauranoid. The absolute configurations of ent-kauranoids 1 and 2 were determined by single-crystal X-ray diffraction analyses. Structural analysis of intermediate compounds 3-5 indicated that eriocalyxin B (6) is a biogenetic precursor of caged ent-kauranoids 1 and 2 as illustrated. The cytotoxic activity of the new compounds was evaluated by an MIT assay. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Caged Diterpenoid Ent-kaurane Isodon Eriocalyx Var. Laxiflora
资助信息The authors are grateful to Professor Xi-Wen Li of the Kunming Institute of Botany, Chinese Academy of Sciences, for identification of the plant. This project was supported financially by the NSFC-Joint Foundation of Yunnan Province (No. U0832602 to H.-D.S), the National Natural Science Foundation of China (No. 81172939 to J.-X.P), the Major State Basic Research Development Program of China (No. 2009CB522300), the reservation-talent project of Yunnan Province (2011C1043 to J.-X. P.), the Science and Technology Program of Yunan Province (Nos. 2008IF010 and 2008CD162), and the Major Direction Projection Foundation of CAS Intellectual Innovation Project (No. 2010KIBA05 to J.-X. P).
学科领域Chemistry
DOI10.1016/j.tetlet.2012.03.112
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000303953200027
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17609
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
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Wang, Wei-Guang,Li, Xiao-Nian,Du, Xue,et al. Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora[J]. TETRAHEDRON LETTERS,2012,53(22):2777-2781.
APA Wang, Wei-Guang.,Li, Xiao-Nian.,Du, Xue.,Dong, Ke.,Zhao, Wei.,...&Sun, Han-Dong.(2012).Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora.TETRAHEDRON LETTERS,53(22),2777-2781.
MLA Wang, Wei-Guang,et al."Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora".TETRAHEDRON LETTERS 53.22(2012):2777-2781.
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