Polycyclic Polyprenylated Acylphloroglucinols and Cytotoxic Constituents of Hypericum androsaemum
Wang, Kou1,2; Wang, Yuan-Yuan1; Gao, Xiu1; Chen, Xuan-Qin1,2; Peng, Li-Yan1; Li, Yan1; Xu, Gang1; Zhao, Qin-Shi1
2012-06-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号9期号:6页码:1213-1220
摘要Two new polycyclic polyprenylated acylphloroglucinols (PPAPs), androforin A and hyperandrone A (1 and 2, resp.), together with twelve known compounds, were isolated from the aerial parts of Hypericum androsaemum. Their structures were established by detailed spectral analysis. In the cytotoxic assay, 1,4-O-diferuloylsecoisolariciresinol (3) showed activities comparable with those of cisplatin, and acetyloleanolic acid (4) exhibited moderate inhibitory effects against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cancer cell lines.
关键词Hypericum Androsaemum Androforin a Hyperandrone a Cytotoxic Activity
资助信息This work was supported by the National Basic Research Program of China (973 Program, No. 2009CB522300) and the National Science Foundation of China (No. 20972167), and the Foundation from CAS (Xibuzhiguang to G. Xu).
学科领域Biochemistry & Molecular Biology ; Chemistry
DOI10.1002/cbdv.201100154
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000305282600019
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17606
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Wang, Kou,Wang, Yuan-Yuan,Gao, Xiu,et al. Polycyclic Polyprenylated Acylphloroglucinols and Cytotoxic Constituents of Hypericum androsaemum[J]. CHEMISTRY & BIODIVERSITY,2012,9(6):1213-1220.
APA Wang, Kou.,Wang, Yuan-Yuan.,Gao, Xiu.,Chen, Xuan-Qin.,Peng, Li-Yan.,...&Zhao, Qin-Shi.(2012).Polycyclic Polyprenylated Acylphloroglucinols and Cytotoxic Constituents of Hypericum androsaemum.CHEMISTRY & BIODIVERSITY,9(6),1213-1220.
MLA Wang, Kou,et al."Polycyclic Polyprenylated Acylphloroglucinols and Cytotoxic Constituents of Hypericum androsaemum".CHEMISTRY & BIODIVERSITY 9.6(2012):1213-1220.
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