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题名: Polycyclic Polyprenylated Acylphloroglucinols and Cytotoxic Constituents of Hypericum androsaemum
作者: Wang, Kou1, 2; Wang, Yuan-Yuan1; Gao, Xiu1; Chen, Xuan-Qin1, 2; Peng, Li-Yan1; null(李艳)1; null(许刚)1; null(赵勤实)1
刊名: CHEMISTRY & BIODIVERSITY
关键词: Hypericum androsaemum ; Androforin A ; Hyperandrone A ; Cytotoxic activity
英文摘要: Two new polycyclic polyprenylated acylphloroglucinols (PPAPs), androforin A and hyperandrone A (1 and 2, resp.), together with twelve known compounds, were isolated from the aerial parts of Hypericum androsaemum. Their structures were established by detailed spectral analysis. In the cytotoxic assay, 1,4-O-diferuloylsecoisolariciresinol (3) showed activities comparable with those of cisplatin, and acetyloleanolic acid (4) exhibited moderate inhibitory effects against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cancer cell lines.
出版日期: 2012-06-01
卷号: 9, 期号:6, 页码:1213-1220
DOI标识: 10.1002/cbdv.201100154
语种: 英语
ISSN号: 1612-1872
资助信息: This work was supported by the National Basic Research Program of China (973 Program, No. 2009CB522300) and the National Science Foundation of China (No. 20972167), and the Foundation from CAS (Xibuzhiguang to G. Xu).
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17606
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Wang,Kou;Wang,Yuan-Yuan;Gao,Xiu;Chen,Xuan-Qin;Peng,Li-Yan;Li,Yan;Xu,Gang;Zhao,Qin-Shi.Polycyclic Polyprenylated Acylphloroglucinols and Cytotoxic Constituents of Hypericum androsaemum,CHEMISTRY & BIODIVERSITY,2012,9(6):1213-1220
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