| Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta | |
Gao, Xue-Mei1,2,3; Niu, De-Yun1,2; Meng, Chun-Yang1,2; Yao, Fu-Quan1,2; Zhou, Bin1,2; Wang, Rui-Rui4; Yang, Liu-Meng4; Zheng, Yong-Tang4; Hu, Qiu-Fen1,2; Sun, Han-Dong3 ; Xiao, Wei-Lie3
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| Corresponding Author | Hu,QF (reprint author),Yunnan Univ Nationalities,State Ethn Affairs Commiss,Key Lab Ethn Med Resource Chem,Kunming 650031,Peoples R China. ; huqiufena@aliyun.com ; xwl@mail.kib.ac.cn |
| 2013-12-01 | |
| Source Publication | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
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| ISSN | 0103-5053 |
| Volume | 24Issue:12Pages:2021-+ |
| Abstract | Four new dibenzocyclooctadiene lignans, neglectalignans A-D (1-4), together with nineteen known compounds (5-23) were isolated from the stems of Schisandra neglecta. Their structures and stereochemistries were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques. Compounds 1-4 were evaluated for their anti-HIV activities and cytotoxicities. The results revealed that compounds 1-4 showed moderate anti-HIV-1 activities with therapeutic index (TI) values above 61.7, 22.6, 57.7, and 27.9, respectively, and weak cytotoxic activities for some selected cell lines. |
| Keyword | Schisandra Neglecta Dibenzocyclooctadiene Lignans Anti-hiv-1 Activities Cytotoxicities |
| Indexed By | SCI ; IC |
| Language | 英语 |
| WOS ID | WOS:000328703200017 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/17451 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China 2.Minist Educ, Kunming 650031, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China |
| Recommended Citation GB/T 7714 | Gao, Xue-Mei,Niu, De-Yun,Meng, Chun-Yang,et al. Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2013,24(12):2021-+. |
| APA | Gao, Xue-Mei.,Niu, De-Yun.,Meng, Chun-Yang.,Yao, Fu-Quan.,Zhou, Bin.,...&Xiao, Wei-Lie.(2013).Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta.JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,24(12),2021-+. |
| MLA | Gao, Xue-Mei,et al."Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta".JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 24.12(2013):2021-+. |
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