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题名: Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta
作者: Gao, Xue-Mei1, 2, 3; Niu, De-Yun1, 2; Meng, Chun-Yang1, 2; Yao, Fu-Quan1, 2; Zhou, Bin1, 2; Wang, Rui-Rui4; Yang, Liu-Meng4; Zheng, Yong-Tang4; Hu, Qiu-Fen1, 2; null(孙汉董)3; Xiao, Wei-Lie3
刊名: JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
关键词: Schisandra neglecta ; dibenzocyclooctadiene lignans ; anti-HIV-1 activities ; cytotoxicities
英文摘要: Four new dibenzocyclooctadiene lignans, neglectalignans A-D (1-4), together with nineteen known compounds (5-23) were isolated from the stems of Schisandra neglecta. Their structures and stereochemistries were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques. Compounds 1-4 were evaluated for their anti-HIV activities and cytotoxicities. The results revealed that compounds 1-4 showed moderate anti-HIV-1 activities with therapeutic index (TI) values above 61.7, 22.6, 57.7, and 27.9, respectively, and weak cytotoxic activities for some selected cell lines.
出版日期: 2013-12-01
卷号: 24, 期号:12, 页码:2021-+
语种: 英语
收录类别: SCI ; IC
ISSN号: 0103-5053
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17451
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China
2.Minist Educ, Kunming 650031, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
4.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China

Recommended Citation:
Gao,Xue-Mei;Niu,De-Yun;Meng,Chun-Yang;Yao,Fu-Quan;Zhou,Bin;Wang,Rui-Rui;Yang,Liu-Meng;Zheng,Yong-Tang;Hu,Qiu-Fen;Sun,Han-Dong;Xiao,Wei-Lie.Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta,JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2013,24(12):2021
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