Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta
Gao, Xue-Mei1,2,3; Niu, De-Yun1,2; Meng, Chun-Yang1,2; Yao, Fu-Quan1,2; Zhou, Bin1,2; Wang, Rui-Rui4; Yang, Liu-Meng4; Zheng, Yong-Tang4; Hu, Qiu-Fen1,2; Sun, Han-Dong3; Xiao, Wei-Lie3
2013-12-01
发表期刊JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
ISSN0103-5053
卷号24期号:12页码:2021-+
摘要Four new dibenzocyclooctadiene lignans, neglectalignans A-D (1-4), together with nineteen known compounds (5-23) were isolated from the stems of Schisandra neglecta. Their structures and stereochemistries were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques. Compounds 1-4 were evaluated for their anti-HIV activities and cytotoxicities. The results revealed that compounds 1-4 showed moderate anti-HIV-1 activities with therapeutic index (TI) values above 61.7, 22.6, 57.7, and 27.9, respectively, and weak cytotoxic activities for some selected cell lines.
关键词Schisandra Neglecta Dibenzocyclooctadiene Lignans Anti-hiv-1 Activities Cytotoxicities
资助信息NSFYP [2012FB178]; Excellent Scientific and Technological Team of Yunnan High School [2010CI08]; Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team [2011HC008]; Open Research Fund Program of Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities) [2010XY08]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17451
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China
2.Minist Educ, Kunming 650031, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
4.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China
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GB/T 7714
Gao, Xue-Mei,Niu, De-Yun,Meng, Chun-Yang,et al. Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2013,24(12):2021-+.
APA Gao, Xue-Mei.,Niu, De-Yun.,Meng, Chun-Yang.,Yao, Fu-Quan.,Zhou, Bin.,...&Xiao, Wei-Lie.(2013).Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta.JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,24(12),2021-+.
MLA Gao, Xue-Mei,et al."Novel Bioactive Dibenzocyclooctadiene Lignans from Schisandra neglecta".JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 24.12(2013):2021-+.
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