Scopariusic Acid, a New Meroditerpenoid with a Unique Cyclobutane Ring Isolated from Isodon scoparius
Zhou, Min1,2; Zhang, Hai-Bo1; Wang, Wei-Guang1; Gong, Ning-Bo3,4; Zhan, Rui1; Li, Xiao-Nian1; Du, Xue1; Li, Li-Mei5; Li, Yan1; Lu, Yang3,4; Pu, Jian-Xin1; Sun, Han-Dong1
2013-09-06
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号15期号:17页码:4446-4449
摘要Scopariusic acid (1), a new ent-clerodane-based meroditerpenoid with a unique cyclobutane ring and an unusual 1-octen-3-ol substituent, together with its biosynthetic related compound 2, were isolated from the aerial parts of Isodon scoparius. The structures of 1 and 2, including their absolute configurations, were determined by spectroscopic methods, single-crystal X-ray diffraction analysis, and chemical methods. Compound 1 showed weak cytotoxicity and moderate immunosuppressive activity.
关键词2+2 Cycloadditions Biyouyanagin-a Biological Evaluation Incarvillea-sinensis Revised Structure Skeleton Littoralisone Alkaloids Diterpene
资助信息National Natural Science Foundation of China [81172939]; Major State Basic Research Development Program of China [2009CB522300]; reservation-talent project of Yunnan Province [2011CI043]; Science and Technology Program of Yunnan Province [2008IF010]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences; National Natural Science Foundation of China(81172939); Major State Basic Research Development Program of China(2009CB522300); reservation-talent project of Yunnan Province(2011CI043); Science and Technology Program of Yunnan Province(2008IF010); Major Direction Projection Foundation of CAS Intellectual Innovation Project(KSCX2-EW-J-24); West Light Foundation of the Chinese Academy of Sciences
DOI10.1021/ol401991u
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000328864800044
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17450
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China
5.Chengdu Med Coll, Res Ctr, Chengdu, Peoples R China
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GB/T 7714
Zhou, Min,Zhang, Hai-Bo,Wang, Wei-Guang,et al. Scopariusic Acid, a New Meroditerpenoid with a Unique Cyclobutane Ring Isolated from Isodon scoparius[J]. ORGANIC LETTERS,2013,15(17):4446-4449.
APA Zhou, Min.,Zhang, Hai-Bo.,Wang, Wei-Guang.,Gong, Ning-Bo.,Zhan, Rui.,...&Sun, Han-Dong.(2013).Scopariusic Acid, a New Meroditerpenoid with a Unique Cyclobutane Ring Isolated from Isodon scoparius.ORGANIC LETTERS,15(17),4446-4449.
MLA Zhou, Min,et al."Scopariusic Acid, a New Meroditerpenoid with a Unique Cyclobutane Ring Isolated from Isodon scoparius".ORGANIC LETTERS 15.17(2013):4446-4449.
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