New steroids and sesquiterpene from Turraea pubescens
Yuan, Chun-Mao1,2; Tang, Gui-Hua2; Wang, Xiao-Ying2; Zhang, Yu2; Cao, Ming-Ming2; Li, Xiao-Hui2; Li, Yan2; Li, Shun-Lin2; Di, Ying-Tong2; He, Hong-Ping2; Hao, Xiao-Jiang2; Hua, Hui-Ming1
2013-10-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号90页码:119-125
摘要Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C-22 steroids isolated from the Meliaceae family for the first time. Their structures were elucidated by extensive NMR and MS analyses. Compound 1 exhibited inhibitory activity against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cells with an IC50 value of 11.5 mu M. (C) 2013 Elsevier B.V. All rights reserved.
关键词Turraea Pubescens Meliaceae Steroids Sesquiterpene Anti-inflammatory
资助信息National Basic Research Program of China (973 Program) [2009CB522300, 2009CB940900];National Natural Science Funding of China [31170332];Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI047]
学科领域Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000326427600016
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17416
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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Yuan, Chun-Mao,Tang, Gui-Hua,Wang, Xiao-Ying,et al. New steroids and sesquiterpene from Turraea pubescens[J]. FITOTERAPIA,2013,90:119-125.
APA Yuan, Chun-Mao.,Tang, Gui-Hua.,Wang, Xiao-Ying.,Zhang, Yu.,Cao, Ming-Ming.,...&Hua, Hui-Ming.(2013).New steroids and sesquiterpene from Turraea pubescens.FITOTERAPIA,90,119-125.
MLA Yuan, Chun-Mao,et al."New steroids and sesquiterpene from Turraea pubescens".FITOTERAPIA 90(2013):119-125.
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