Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia
Huang, Sheng-Zhuo1,4; Zhang, Xuan3; Ma, Qing-Yun1,4; Zheng, Yong-Tang3; Xu, Feng-Qing2; Peng, Hua2; Dai, Hao-Fu1,4; Zhou, Jun2; Zhao, You-Xing1,4
Corresponding AuthorZhou,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.,junzhou3264@126.com ; zhaoyouxing@itbb.org.cn
2013-12-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume91Pages:224-230
AbstractFive new diterpenoids named excocarinols A-E (1-5) including three pimaranes, one cleistanthane, and one nor-beyerane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58 mu M and SI (Selection Index) over 112.71. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
KeywordExcoecaria Acerifolia Euphorbiaceae Anti-hiv Diterpenoid Triterpenoid
Subject AreaPharmacology & Pharmacy
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000327574300033
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17402
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech Chinese Acad, Kunming Inst Zool, Kunming 650223, Peoples R China
4.Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Peoples R China
Recommended Citation
GB/T 7714
Huang, Sheng-Zhuo,Zhang, Xuan,Ma, Qing-Yun,et al. Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia[J]. FITOTERAPIA,2013,91:224-230.
APA Huang, Sheng-Zhuo.,Zhang, Xuan.,Ma, Qing-Yun.,Zheng, Yong-Tang.,Xu, Feng-Qing.,...&Zhao, You-Xing.(2013).Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia.FITOTERAPIA,91,224-230.
MLA Huang, Sheng-Zhuo,et al."Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia".FITOTERAPIA 91(2013):224-230.
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