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题名: Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia
作者: Huang, Sheng-Zhuo1, 4; Zhang, Xuan3; Ma, Qing-Yun1, 4; Zheng, Yong-Tang3; Xu, Feng-Qing2; null(彭华)2; Dai, Hao-Fu1, 4; Zhou, Jun2; Zhao, You-Xing1, 4
刊名: FITOTERAPIA
关键词: Excoecaria acerifolia ; Euphorbiaceae ; Anti-HIV ; Diterpenoid ; Triterpenoid
英文摘要: Five new diterpenoids named excocarinols A-E (1-5) including three pimaranes, one cleistanthane, and one nor-beyerane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58 mu M and SI (Selection Index) over 112.71. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
出版日期: 2013-12-01
卷号: 91, 页码:224-230
语种: 英语
ISSN号: 0367-326X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17402
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech Chinese Acad, Kunming Inst Zool, Kunming 650223, Peoples R China
4.Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Peoples R China

Recommended Citation:
Huang,Sheng-Zhuo;Zhang,Xuan;Ma,Qing-Yun;Zheng,Yong-Tang;Xu,Feng-Qing;Peng,Hua;Dai,Hao-Fu;Zhou,Jun;Zhao,You-Xing.Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia,FITOTERAPIA,2013,91():224-230
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