The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry
Huang, Ning1,4; Wu, Ming-Yi2; Zheng, Chang-Bo3; Zhu, Lin1; Zhao, Jin-Hua2; Zheng, Yong-Tang1
2013-10-18
发表期刊CARBOHYDRATE RESEARCH
ISSN0008-6215
卷号380页码:64-69
摘要Fucosylated chondroitin sulfate (FuCS-1) is a nontoxic and water-soluble depolymerized glycosaminoglycan obtained from the sea cucumber Thelenota ananas. Anti-HIV activities of FuCS-1 were evaluated in the present study. FuCS-1 was effective in blocking laboratory strain HIV-1(IIIB) entry and replication (4.26 mu g/mL and 0.73 mu g/mL, respectively), and inhibiting infection by clinic isolate HIV-1(KM018) and HIV-1(TC-2) (23.75 mu g/mL and 31.86 mu g/mL, respectively) as well as suppressing HIV-1 drug-resistant virus. It also inhibited HIV-2(ROD) and HIV-2(CBL-20) replication (100 mu g/mL). Notably, FuCS-1 showed highly effective antiviral activity against T-20-resistant strains (EC50 values ranging from 0.76 mu g/mL to 1.13 mu g/mL). Further studies indicated that FuCS-1 can potently bind the recombinant HIV-1 gp120 protein, but no inhibition of recombinant HIV-1 reverse transcriptase was observed. In conclusion, FuCS-1 inhibited several strains of HIV-1 replication with different potencies. These results suggest that FuCS-1 may possess great potential to be further developed as novel HIV-1 entry inhibitor for treatment of HIV/AIDS patients, particularly for those infected by T-20-resistant variants. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Fucosylated Chondroitin Sulfate Hiv-1 Anti-hiv Agent Hiv Entry
资助信息National Natural Science Foundation of China [81102483, 81001462, 81102372]; 973 Program [2009CB522306]; Key Scientific and Technological Program of China [2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007, 2012ZX09103-101-022]; Key Scientific and Technological Program of Yunnan [2007BC006, 2010GA001, 2012BC011]
学科领域Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
WOS记录号WOS:000325167400010
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17288
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
3.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China
4.Kunming Med Univ, Sch Basic Med, Kunming 650500, Yunnan, Peoples R China
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Huang, Ning,Wu, Ming-Yi,Zheng, Chang-Bo,et al. The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry[J]. CARBOHYDRATE RESEARCH,2013,380:64-69.
APA Huang, Ning,Wu, Ming-Yi,Zheng, Chang-Bo,Zhu, Lin,Zhao, Jin-Hua,&Zheng, Yong-Tang.(2013).The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry.CARBOHYDRATE RESEARCH,380,64-69.
MLA Huang, Ning,et al."The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry".CARBOHYDRATE RESEARCH 380(2013):64-69.
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