| Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi | |
Wu, Xing-De1; He, Juan1; Li, Xing-Yao1; Dong, Liao-Bin1; Gong, Xun1 ; Gao, Xiu1; Song, Liu-Dong2,3; Li, Yan1; Peng, Li-Yan1; Zhao, Qin-Shi1
| |
| 通讯作者 | Zhao, QS (reprint author), State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China.,ynsld@126.com |
| 2013-09-01 | |
| 发表期刊 | PLANTA MEDICA
 |
| ISSN | 0032-0943 |
| 卷号 | 79期号:14页码:1356-1361 |
| 摘要 | Two new ursane-type triterpenoids, 3,19,23-trihydroxyurs-12-en-24-al-28-oic acid (1) and 3,19,24-trihydroxy-23-norurs-12-en-28-oic acid (2), two new pregnane derivatives, 3,12-dihydroxy-5-pregnane-14,16-dien-20-one (9) and 12-hydroxy-5-pregnane-14,16-dien-3,20-dione (10), and eight known compounds were isolated from the twigs and leaves of Emmenopterys henryi. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 4, 11, and 12 showed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines with IC50 values in the range of 3.11-20.12 mu M. |
| 关键词 | Emmenopterys Henryi Rubiaceae Ursane-type Triterpenoids Pregnane Derivatives Cytotoxic Activity |
| 学科领域 | Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000324892000011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17286 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Xing-De,He, Juan,Li, Xing-Yao,et al. Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi[J]. PLANTA MEDICA,2013,79(14):1356-1361. |
| APA | Wu, Xing-De.,He, Juan.,Li, Xing-Yao.,Dong, Liao-Bin.,Gong, Xun.,...&Zhao, Qin-Shi.(2013).Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi.PLANTA MEDICA,79(14),1356-1361. |
| MLA | Wu, Xing-De,et al."Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi".PLANTA MEDICA 79.14(2013):1356-1361. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Triterpenoids and St（172KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论