Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi
Wu, Xing-De1; He, Juan1; Li, Xing-Yao1; Dong, Liao-Bin1; Gong, Xun1; Gao, Xiu1; Song, Liu-Dong2,3; Li, Yan1; Peng, Li-Yan1; Zhao, Qin-Shi1
2013-09-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号79期号:14页码:1356-1361
摘要Two new ursane-type triterpenoids, 3,19,23-trihydroxyurs-12-en-24-al-28-oic acid (1) and 3,19,24-trihydroxy-23-norurs-12-en-28-oic acid (2), two new pregnane derivatives, 3,12-dihydroxy-5-pregnane-14,16-dien-20-one (9) and 12-hydroxy-5-pregnane-14,16-dien-3,20-dione (10), and eight known compounds were isolated from the twigs and leaves of Emmenopterys henryi. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 4, 11, and 12 showed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines with IC50 values in the range of 3.11-20.12 mu M.
关键词Emmenopterys Henryi Rubiaceae Ursane-type Triterpenoids Pregnane Derivatives Cytotoxic Activity
资助信息National Basic Research Program of China (973 Program) [2009CB522303, 2011CB915503]; National Natural Science Foundation of China [90813004, U0932602]; Chinese Academy of Sciences [2009311211011, 2009312311024]
学科领域Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000324892000011
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17286
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
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Wu, Xing-De,He, Juan,Li, Xing-Yao,et al. Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi[J]. PLANTA MEDICA,2013,79(14):1356-1361.
APA Wu, Xing-De.,He, Juan.,Li, Xing-Yao.,Dong, Liao-Bin.,Gong, Xun.,...&Zhao, Qin-Shi.(2013).Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi.PLANTA MEDICA,79(14),1356-1361.
MLA Wu, Xing-De,et al."Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi".PLANTA MEDICA 79.14(2013):1356-1361.
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