Two new ursane-type triterpenoids, 3,19,23-trihydroxyurs-12-en-24-al-28-oic acid (1) and 3,19,24-trihydroxy-23-norurs-12-en-28-oic acid (2), two new pregnane derivatives, 3,12-dihydroxy-5-pregnane-14,16-dien-20-one (9) and 12-hydroxy-5-pregnane-14,16-dien-3,20-dione (10), and eight known compounds were isolated from the twigs and leaves of Emmenopterys henryi. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 4, 11, and 12 showed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines with IC50 values in the range of 3.11-20.12 mu M.
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
