| Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta | |
Gao, Xue-Mei1,2,3; Wang, Rui-Rui5,6; Niu, De-Yun2,3,4; Meng, Chun-Yang2,3,4; Yang, Liu-Meng5,6; Zheng, Yong-Tang5,6; Yang, Guang-Yu1,4; Hu, Qiu-Fen2,3; Sun, Han-Dong1 ; Xiao, Wei-Lie1
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| 通讯作者 | Hu, QF (reprint author), Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Yunnan, Peoples R China. ; huqiufena@yahoo.com.cn ; xwl@mail.kib.ac.cn |
| 2013-06-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 76期号:6页码:1052-1057 |
| 摘要 | Seven new unusual dibenzocyclooctadiene lignans, neglignans A-G (1-7), together with 16 known dibenzocyclooctadiene lignans, were isolated from the stems of Schisandra neglecta. Compounds 1 and 2 are the first dibenzocyclooctadiene lignans bearing a carboxyl group at C-4, and compounds 3 and 4 are the first 7,8-seco-dibenzocyclooctadiene lignans found from Nature. The new compounds (1-7) and several of the known compounds were evaluated for their anti-HIV activity and cytotoxicity. Compounds 2 and 6 showed anti-HIV-1 activities with therapeutic index values greater than 50, and compound 4 showed cytotoxicity against the NB4 and SHSY5Y cancer cell lines with IC50 values of 2.9 and 3.3 mu M, respectively. |
| 关键词 | Schizandra-chinensis Baill Anti-hiv-1 Activities Constituents Gomisin Sphenanthera Kadsura |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000321320600009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16773 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Yunnan, Peoples R China 3.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Yunnan, Peoples R China 4.Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 6.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Xue-Mei,Wang, Rui-Rui,Niu, De-Yun,et al. Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(6):1052-1057. |
| APA | Gao, Xue-Mei.,Wang, Rui-Rui.,Niu, De-Yun.,Meng, Chun-Yang.,Yang, Liu-Meng.,...&Xiao, Wei-Lie.(2013).Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta.JOURNAL OF NATURAL PRODUCTS,76(6),1052-1057. |
| MLA | Gao, Xue-Mei,et al."Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta".JOURNAL OF NATURAL PRODUCTS 76.6(2013):1052-1057. |
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