Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta
Gao, Xue-Mei1,2,3; Wang, Rui-Rui5,6; Niu, De-Yun2,3,4; Meng, Chun-Yang2,3,4; Yang, Liu-Meng5,6; Zheng, Yong-Tang5,6; Yang, Guang-Yu1,4; Hu, Qiu-Fen2,3; Sun, Han-Dong1; Xiao, Wei-Lie1
2013-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:6页码:1052-1057
摘要Seven new unusual dibenzocyclooctadiene lignans, neglignans A-G (1-7), together with 16 known dibenzocyclooctadiene lignans, were isolated from the stems of Schisandra neglecta. Compounds 1 and 2 are the first dibenzocyclooctadiene lignans bearing a carboxyl group at C-4, and compounds 3 and 4 are the first 7,8-seco-dibenzocyclooctadiene lignans found from Nature. The new compounds (1-7) and several of the known compounds were evaluated for their anti-HIV activity and cytotoxicity. Compounds 2 and 6 showed anti-HIV-1 activities with therapeutic index values greater than 50, and compound 4 showed cytotoxicity against the NB4 and SHSY5Y cancer cell lines with IC50 values of 2.9 and 3.3 mu M, respectively.
关键词Schizandra-chinensis Baill Anti-hiv-1 Activities Constituents Gomisin Sphenanthera Kadsura
资助信息CAS [KSCX2-EW-Q-10, KSCX1-YW-R-24]; Natural Science Foundation of Yunnan Province [2012FB178]; NSFC [20802082, 30830115]; 973 Programs [2009CB522300, 2009CB940900]; Excellent Scientific and Technological Team of Yunnan Higher Education [2010CI08]; Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team [2011HC008]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000321320600009
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16773
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Yunnan, Peoples R China
3.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Yunnan, Peoples R China
4.Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Yunnan, Peoples R China
5.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
6.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China
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GB/T 7714
Gao, Xue-Mei,Wang, Rui-Rui,Niu, De-Yun,et al. Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(6):1052-1057.
APA Gao, Xue-Mei.,Wang, Rui-Rui.,Niu, De-Yun.,Meng, Chun-Yang.,Yang, Liu-Meng.,...&Xiao, Wei-Lie.(2013).Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta.JOURNAL OF NATURAL PRODUCTS,76(6),1052-1057.
MLA Gao, Xue-Mei,et al."Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta".JOURNAL OF NATURAL PRODUCTS 76.6(2013):1052-1057.
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