Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells
Liu, Ying1,2; Dong, Ying3; Zhang, Bo4; Cheng, Yong-Xian5
2013-08-01
发表期刊ONCOLOGY LETTERS
ISSN1792-1074
卷号6期号:2页码:556-558
摘要6-O-angeloylplenolin (6-OAP) is a sesquiterpene lactone agent that has been previously demonstrated to inhibit the growth of multiple myeloma (MM) cells through mitotic arrest with accumulated cyclin B1. In the present study, the levels of apoptosis were analyzed in dexamethasone-sensitive (MM.1S), dexamethasone-resistant (U266) and chemotherapy-sensitive (RPMI 8226) myeloma cell lines. Enhanced apoptosis was identified following a 48-h incubation with 6-OAP (0-10 mu M) that induced a dose-dependent decrease in pro-casp-3 and the cleavage of its substrate, anti-poly (ADP-ribose) polymerase (PARP). In addition, time-dependent cleavage of PARP was also detected in U266 and MM.1S cells. The mechanism of 6-OAP cytotoxicity in all cell lines was associated with the induction of apoptosis with the presence of cleaved caspase-3 and PARP. In conclusion, 6-OAP-induced apoptosis is caspase-dependent. These observations are likely to provide a framework for future studies of 6-OAP therapy in MM.
关键词6-o-angeloylplenolin Multiple Myeloma Apoptosis Caspase
资助信息National Natural Science Foundation of China [81101835]; Foundation of Zhejiang Provincial Education Department [Y200804683]; National Natural Science Foundation of China(81101835); Foundation of Zhejiang Provincial Education Department(Y200804683)
学科领域Oncology
DOI10.3892/ol.2013.1370
收录类别SCI
语种英语
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000322381000049
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16719
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Tsinghua Univ, Grad Sch Shenzhen, Ctr Biotech & BioMed, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
2.Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R China
3.Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Oncol, Hangzhou 310009, Zhejiang, Peoples R China
4.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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Liu, Ying,Dong, Ying,Zhang, Bo,et al. Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells[J]. ONCOLOGY LETTERS,2013,6(2):556-558.
APA Liu, Ying,Dong, Ying,Zhang, Bo,&Cheng, Yong-Xian.(2013).Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells.ONCOLOGY LETTERS,6(2),556-558.
MLA Liu, Ying,et al."Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells".ONCOLOGY LETTERS 6.2(2013):556-558.
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