Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus

	Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus
	Zhao, Jian-Qiang 1,2; Lv, Jun-Jiang 1,2; Wang, Yan-Ming 1,2; Xu, Min 1; Zhu, Hong-Tao 1; Wang, Dong1 ; Yang, Chong-Ren 1; Wang, Yi-Fei 3; Zhang, Ying-Jun1
通讯作者	Xu, M (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; xumin@mail.kib.ac.cn ; zhangyj@mail.kib.ac.cn
	2013-08-28
发表期刊	TETRAHEDRON LETTERS
ISSN	0040-4039
卷号	54 期号:35 页码:4670-4674
摘要	Three structurally interesting new diterpenoids, phyllanflexoids A-C(1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1-3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5 mu M, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
关键词	18-nor-diterpenoid Glycoside Phyllanthus Flexuosus Phenylacetylene Phyllanflexoids A-c Cytotoxic Activity
学科领域	Chemistry, Organic
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000323020400017
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16691
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Jian-Qiang,Lv, Jun-Jiang,Wang, Yan-Ming,et al. Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus[J]. TETRAHEDRON LETTERS,2013,54(35):4670-4674.
APA	Zhao, Jian-Qiang.,Lv, Jun-Jiang.,Wang, Yan-Ming.,Xu, Min.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2013).Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus.TETRAHEDRON LETTERS,54(35),4670-4674.
MLA	Zhao, Jian-Qiang,et al."Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus".TETRAHEDRON LETTERS 54.35(2013):4670-4674.

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