| Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus | |
Zhao, Jian-Qiang1,2; Lv, Jun-Jiang1,2; Wang, Yan-Ming1,2; Xu, Min1; Zhu, Hong-Tao1; Wang, Dong1 ; Yang, Chong-Ren1; Wang, Yi-Fei3; Zhang, Ying-Jun1
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| 通讯作者 | Xu, M (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; xumin@mail.kib.ac.cn ; zhangyj@mail.kib.ac.cn |
| 2013-08-28 | |
| 发表期刊 | TETRAHEDRON LETTERS
 |
| ISSN | 0040-4039 |
| 卷号 | 54期号:35页码:4670-4674 |
| 摘要 | Three structurally interesting new diterpenoids, phyllanflexoids A-C(1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1-3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5 mu M, respectively. (C) 2013 Elsevier Ltd. All rights reserved. |
| 关键词 | 18-nor-diterpenoid Glycoside Phyllanthus Flexuosus Phenylacetylene Phyllanflexoids A-c Cytotoxic Activity |
| 学科领域 | Chemistry, Organic |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000323020400017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16691 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Jian-Qiang,Lv, Jun-Jiang,Wang, Yan-Ming,et al. Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus[J]. TETRAHEDRON LETTERS,2013,54(35):4670-4674. |
| APA | Zhao, Jian-Qiang.,Lv, Jun-Jiang.,Wang, Yan-Ming.,Xu, Min.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2013).Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus.TETRAHEDRON LETTERS,54(35),4670-4674. |
| MLA | Zhao, Jian-Qiang,et al."Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus".TETRAHEDRON LETTERS 54.35(2013):4670-4674. |
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