Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus
Zhao, Jian-Qiang1,2; Lv, Jun-Jiang1,2; Wang, Yan-Ming1,2; Xu, Min1; Zhu, Hong-Tao1; Wang, Dong1; Yang, Chong-Ren1; Wang, Yi-Fei3; Zhang, Ying-Jun1
Corresponding AuthorXu, M (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; xumin@mail.kib.ac.cn ; zhangyj@mail.kib.ac.cn
2013-08-28
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume54Issue:35Pages:4670-4674
AbstractThree structurally interesting new diterpenoids, phyllanflexoids A-C(1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1-3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5 mu M, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
Keyword18-nor-diterpenoid Glycoside Phyllanthus Flexuosus Phenylacetylene Phyllanflexoids A-c Cytotoxic Activity
Subject AreaChemistry, Organic
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000323020400017
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16691
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Jian-Qiang,Lv, Jun-Jiang,Wang, Yan-Ming,et al. Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus[J]. TETRAHEDRON LETTERS,2013,54(35):4670-4674.
APA Zhao, Jian-Qiang.,Lv, Jun-Jiang.,Wang, Yan-Ming.,Xu, Min.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2013).Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus.TETRAHEDRON LETTERS,54(35),4670-4674.
MLA Zhao, Jian-Qiang,et al."Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus".TETRAHEDRON LETTERS 54.35(2013):4670-4674.
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