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题名: Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus
作者: Zhao, Jian-Qiang1, 2; Lv, Jun-Jiang1, 2; Wang, Yan-Ming1, 2; Xu, Min1; Zhu, Hong-Tao1; Wang, Dong1; Yang, Chong-Ren1; Wang, Yi-Fei3; null(张颖君)1
刊名: TETRAHEDRON LETTERS
关键词: 18-Nor-diterpenoid glycoside ; Phyllanthus flexuosus ; Phenylacetylene ; Phyllanflexoids A-C ; Cytotoxic activity
英文摘要: Three structurally interesting new diterpenoids, phyllanflexoids A-C(1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1-3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5 mu M, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
出版日期: 2013-08-28
卷号: 54, 期号:35, 页码:4670-4674
语种: 英语
ISSN号: 0040-4039
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16691
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China

Recommended Citation:
Zhao, Jian-Qiang; Lv, Jun-Jiang; Wang, Yan-Ming; Xu, Min; Zhu, Hong-Tao; Wang, Dong; Yang, Chong-Ren; Wang, Yi-Fei; Zhang, Ying-Jun.Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus,TETRAHEDRON LETTERS,2013,54(35):4670-4674
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