Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus
Zhao, Jian-Qiang1,2; Lv, Jun-Jiang1,2; Wang, Yan-Ming1,2; Xu, Min1; Zhu, Hong-Tao1; Wang, Dong1; Yang, Chong-Ren1; Wang, Yi-Fei3; Zhang, Ying-Jun1
2013-08-28
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号54期号:35页码:4670-4674
摘要Three structurally interesting new diterpenoids, phyllanflexoids A-C(1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1-3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5 mu M, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
关键词18-nor-diterpenoid Glycoside Phyllanthus Flexuosus Phenylacetylene Phyllanflexoids A-c Cytotoxic Activity
资助信息NSFC [21002105]; 973 Program of Science and Technology of People's Republic of China [2011CB915503]; Fourteenth Batch Candidates of the Young Academic Leaders of Yunnan Province [2011CI044]; West Light Foundation of the Chinese Academy of Sciences
学科领域Chemistry, Organic
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000323020400017
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16691
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
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Zhao, Jian-Qiang,Lv, Jun-Jiang,Wang, Yan-Ming,et al. Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus[J]. TETRAHEDRON LETTERS,2013,54(35):4670-4674.
APA Zhao, Jian-Qiang.,Lv, Jun-Jiang.,Wang, Yan-Ming.,Xu, Min.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2013).Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus.TETRAHEDRON LETTERS,54(35),4670-4674.
MLA Zhao, Jian-Qiang,et al."Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus".TETRAHEDRON LETTERS 54.35(2013):4670-4674.
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