Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity
Li, Shi-Fei1,2; Zhang, Yu1; Huang, Ning2,3; Zheng, Yong-Tang3; Di, Ying-Tong1; Li, Shun-Lin1; Cheng, Yuan-Yuan1,2; He, Hong-Ping1; Hao, Xiao-Jiang1
Corresponding AuthorHe, HP (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; hehongping@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
2013-09-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume93Pages:216-221
AbstractThirteen highly oxygenated daphnane diterpenoids, including six known compounds, were isolated from the stems of Trigonostemon lii. The structures were elucidated by extensive spectroscopic analyses including 2D NMR spectroscopy (HSQC, H-1-H-1 COSY, HMBC, and ROESY) and mass spectrometry. The absolute stereochemistries of compounds were established on the basis of CD spectra. Four of the compounds showed modest anti-HIV-1 activity (EC50 = 2.04, 9.17, 11.42, and 9.05 mu g/ml, TI = 26.49, >21.81, 9.32, and 9.56, respectively) in vitro. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordTrigonostemon Lii Euphorbiaceae Daphnane Diterpenoids Trigolins A-g Anti-hiv-1 Activity
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2013.03.003
Indexed BySCI ; IC
Language英语
WOS IDWOS:000323630000025
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16685
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming 650223, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Shi-Fei,Zhang, Yu,Huang, Ning,et al. Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity[J]. PHYTOCHEMISTRY,2013,93:216-221.
APA Li, Shi-Fei.,Zhang, Yu.,Huang, Ning.,Zheng, Yong-Tang.,Di, Ying-Tong.,...&Hao, Xiao-Jiang.(2013).Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity.PHYTOCHEMISTRY,93,216-221.
MLA Li, Shi-Fei,et al."Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity".PHYTOCHEMISTRY 93(2013):216-221.
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