Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity
Li, Shi-Fei1,2; Zhang, Yu1; Huang, Ning2,3; Zheng, Yong-Tang3; Di, Ying-Tong1; Li, Shun-Lin1; Cheng, Yuan-Yuan1,2; He, Hong-Ping1; Hao, Xiao-Jiang1
2013-09-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号93页码:216-221
摘要Thirteen highly oxygenated daphnane diterpenoids, including six known compounds, were isolated from the stems of Trigonostemon lii. The structures were elucidated by extensive spectroscopic analyses including 2D NMR spectroscopy (HSQC, H-1-H-1 COSY, HMBC, and ROESY) and mass spectrometry. The absolute stereochemistries of compounds were established on the basis of CD spectra. Four of the compounds showed modest anti-HIV-1 activity (EC50 = 2.04, 9.17, 11.42, and 9.05 mu g/ml, TI = 26.49, >21.81, 9.32, and 9.56, respectively) in vitro. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Trigonostemon Lii Euphorbiaceae Daphnane Diterpenoids Trigolins A-g Anti-hiv-1 Activity
资助信息Ministry of Science and Technology of China [2009CB522300, 2009CB940900]; National Natural Science Funding of China [21072199]; Natural Science Funding of Yunnan Province [2009CD112]; Foundation of Chinese Academy of Sciences; Yong Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI047]; Ministry of Science and Technology of China(2009CB522300; National Natural Science Funding of China(21072199); Natural Science Funding of Yunnan Province(2009CD112); Foundation of Chinese Academy of Sciences; Yong Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047); 2009CB940900)
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2013.03.003
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000323630000025
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16685
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming 650223, Yunnan, Peoples R China
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Li, Shi-Fei,Zhang, Yu,Huang, Ning,et al. Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity[J]. PHYTOCHEMISTRY,2013,93:216-221.
APA Li, Shi-Fei.,Zhang, Yu.,Huang, Ning.,Zheng, Yong-Tang.,Di, Ying-Tong.,...&Hao, Xiao-Jiang.(2013).Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity.PHYTOCHEMISTRY,93,216-221.
MLA Li, Shi-Fei,et al."Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity".PHYTOCHEMISTRY 93(2013):216-221.
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