Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling
Yin, Qian-Qian1,2; Liu, Chuan-Xu3; Wu, Ying-Li3; Wu, Shao-Fang1,2; Wang, Yan4; Zhang, Xia4; Hu, Xiao-Juan4; Pu, Jian-Xin5; Lu, Ying3; Zhou, Hu-Chen3; Wang, Hong-Lin4; Nie, Hong4; Sun, Han-Dong5; Chen, Guo-Qiang1,2,3
2013-09-01
发表期刊JOURNAL OF IMMUNOLOGY
ISSN0022-1767
卷号191期号:5页码:2115-2125
摘要

Adenanthin, a diterpenoid isolated from the leaves of Isodon adenanthus, has been reported to possess antileukemic activity through targeting peroxiredoxin I/II. However, its other potential activities remain to be explored. Using myelin oligodendrocyte glycoprotein (MOG)(35-55)-induced experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, we report in this study that adenanthin exerts efficaciously preventive and therapeutic effects on EAE accompanied by significant restriction of infiltration of inflammatory cells and demyelination in CNS. Adenanthin-presented immunomodulatory effects on EAE are correlated with suppressed proliferation of MOG(35-55)-reactive T cells, decreased Th1 and Th17 cells, increased regulatory T cell populations, decreased production of serum proinflammatory cytokines, and reduced stimulatory capacity of APCs, which might be mediated by its inhibitory action on NF-kappa B signaling pathway. Our results propose that, as a novel NF-kappa B inhibitor, adenanthin has potent immunomodulatory activity for the treatment of multiple sclerosis and possibly other autoimmune disorders.

关键词Autoreactive T-cells Multiple-sclerosis Rheumatoid-arthritis Glatiramer Acetate Activation Inflammation System Roles Mice Differentiation
资助信息National Basic Research Program of China [2009CB918404]; National Natural Science Foundation of China [81070433, 81172939]; Foundation for the Author of National Excellent Doctoral Dissertation of China [201074]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16671
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China
3.Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Shanghai Univ E Inst Chem Biol, Dept Pathophysiol,Sch Med,Chinese Minist Educ, Shanghai 200025, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Inst Immunol, Shanghai 200025, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource West Chi, Kunming 650201, Peoples R China
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Yin, Qian-Qian,Liu, Chuan-Xu,Wu, Ying-Li,et al. Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling[J]. JOURNAL OF IMMUNOLOGY,2013,191(5):2115-2125.
APA Yin, Qian-Qian.,Liu, Chuan-Xu.,Wu, Ying-Li.,Wu, Shao-Fang.,Wang, Yan.,...&Chen, Guo-Qiang.(2013).Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling.JOURNAL OF IMMUNOLOGY,191(5),2115-2125.
MLA Yin, Qian-Qian,et al."Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling".JOURNAL OF IMMUNOLOGY 191.5(2013):2115-2125.
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