Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling
Yin, Qian-Qian1,2; Liu, Chuan-Xu3; Wu, Ying-Li3; Wu, Shao-Fang1,2; Wang, Yan4; Zhang, Xia4; Hu, Xiao-Juan4; Pu, Jian-Xin5; Lu, Ying3; Zhou, Hu-Chen3; Wang, Hong-Lin4; Nie, Hong4; Sun, Han-Dong5; Chen, Guo-Qiang1,2,3
2013-09-01
发表期刊JOURNAL OF IMMUNOLOGY
ISSN0022-1767
卷号191期号:5页码:2115-2125
摘要Adenanthin, a diterpenoid isolated from the leaves of Isodon adenanthus, has been reported to possess antileukemic activity through targeting peroxiredoxin I/II. However, its other potential activities remain to be explored. Using myelin oligodendrocyte glycoprotein (MOG)(35-55)-induced experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, we report in this study that adenanthin exerts efficaciously preventive and therapeutic effects on EAE accompanied by significant restriction of infiltration of inflammatory cells and demyelination in CNS. Adenanthin-presented immunomodulatory effects on EAE are correlated with suppressed proliferation of MOG(35-55)-reactive T cells, decreased Th1 and Th17 cells, increased regulatory T cell populations, decreased production of serum proinflammatory cytokines, and reduced stimulatory capacity of APCs, which might be mediated by its inhibitory action on NF-kappa B signaling pathway. Our results propose that, as a novel NF-kappa B inhibitor, adenanthin has potent immunomodulatory activity for the treatment of multiple sclerosis and possibly other autoimmune disorders.
关键词Autoreactive T-cells Multiple-sclerosis Rheumatoid-arthritis Glatiramer Acetate Activation Inflammation System Roles Mice Differentiation
资助信息National Basic Research Program of China [2009CB918404]; National Natural Science Foundation of China [81070433, 81172939]; Foundation for the Author of National Excellent Doctoral Dissertation of China [201074]
学科领域Immunology
收录类别SCI
语种英语
WOS研究方向Immunology
WOS类目Immunology
WOS记录号WOS:000323393300012
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16671
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China
3.Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Shanghai Univ E Inst Chem Biol, Dept Pathophysiol,Sch Med,Chinese Minist Educ, Shanghai 200025, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Inst Immunol, Shanghai 200025, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource West Chi, Kunming 650201, Peoples R China
推荐引用方式
GB/T 7714
Yin, Qian-Qian,Liu, Chuan-Xu,Wu, Ying-Li,et al. Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling[J]. JOURNAL OF IMMUNOLOGY,2013,191(5):2115-2125.
APA Yin, Qian-Qian.,Liu, Chuan-Xu.,Wu, Ying-Li.,Wu, Shao-Fang.,Wang, Yan.,...&Chen, Guo-Qiang.(2013).Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling.JOURNAL OF IMMUNOLOGY,191(5),2115-2125.
MLA Yin, Qian-Qian,et al."Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling".JOURNAL OF IMMUNOLOGY 191.5(2013):2115-2125.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
JI-CGQ.pdf(2420KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yin, Qian-Qian]的文章
[Liu, Chuan-Xu]的文章
[Wu, Ying-Li]的文章
百度学术
百度学术中相似的文章
[Yin, Qian-Qian]的文章
[Liu, Chuan-Xu]的文章
[Wu, Ying-Li]的文章
必应学术
必应学术中相似的文章
[Yin, Qian-Qian]的文章
[Liu, Chuan-Xu]的文章
[Wu, Ying-Li]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。