Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling
Yin, Qian-Qian1,2; Liu, Chuan-Xu3; Wu, Ying-Li3; Wu, Shao-Fang1,2; Wang, Yan4; Zhang, Xia4; Hu, Xiao-Juan4; Pu, Jian-Xin5; Lu, Ying3; Zhou, Hu-Chen3; Wang, Hong-Lin4; Nie, Hong4; Sun, Han-Dong5; Chen, Guo-Qiang1,2,3
Corresponding AuthorChen, GQ (reprint author), Shanghai Jiao Tong Univ, Sch Med, 280 Chongqing South Rd, Shanghai 200025, Peoples R China. ; hdsun@mail.kib.ac.cn ; chengq@shsmu.edu.cn
2013-09-01
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume191Issue:5Pages:2115-2125
Abstract

Adenanthin, a diterpenoid isolated from the leaves of Isodon adenanthus, has been reported to possess antileukemic activity through targeting peroxiredoxin I/II. However, its other potential activities remain to be explored. Using myelin oligodendrocyte glycoprotein (MOG)(35-55)-induced experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, we report in this study that adenanthin exerts efficaciously preventive and therapeutic effects on EAE accompanied by significant restriction of infiltration of inflammatory cells and demyelination in CNS. Adenanthin-presented immunomodulatory effects on EAE are correlated with suppressed proliferation of MOG(35-55)-reactive T cells, decreased Th1 and Th17 cells, increased regulatory T cell populations, decreased production of serum proinflammatory cytokines, and reduced stimulatory capacity of APCs, which might be mediated by its inhibitory action on NF-kappa B signaling pathway. Our results propose that, as a novel NF-kappa B inhibitor, adenanthin has potent immunomodulatory activity for the treatment of multiple sclerosis and possibly other autoimmune disorders.

KeywordAutoreactive T-cells Multiple-sclerosis Rheumatoid-arthritis Glatiramer Acetate Activation Inflammation System Roles Mice Differentiation
Subject AreaImmunology
Indexed BySCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000323393300012
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16671
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China
3.Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Shanghai Univ E Inst Chem Biol, Dept Pathophysiol,Sch Med,Chinese Minist Educ, Shanghai 200025, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Inst Immunol, Shanghai 200025, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource West Chi, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Yin, Qian-Qian,Liu, Chuan-Xu,Wu, Ying-Li,et al. Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling[J]. JOURNAL OF IMMUNOLOGY,2013,191(5):2115-2125.
APA Yin, Qian-Qian.,Liu, Chuan-Xu.,Wu, Ying-Li.,Wu, Shao-Fang.,Wang, Yan.,...&Chen, Guo-Qiang.(2013).Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling.JOURNAL OF IMMUNOLOGY,191(5),2115-2125.
MLA Yin, Qian-Qian,et al."Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kappa B Signaling".JOURNAL OF IMMUNOLOGY 191.5(2013):2115-2125.
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