| Chemical constituents of Arisaema franchetianum tubers | |
Su, Yao1,2; Xu, Jin-Jin1; Bi, Jun-Long3; Wang, Yue-Hu1 ; Hu, Guang-Wan1; Yang, Jun1; Yin, Ge-Fen3; Long, Chun-Lin1,4
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| 通讯作者 | Yin, GF (reprint author), Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China. ; yingefen383@sohu.com ; long@mail.kib.ac.cn |
| 2013 | |
| 发表期刊 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| ISSN | 1028-6020 |
| 卷号 | 15期号:1页码:71-77 |
| 摘要 | A novel pyrrolidine alkaloid, (2R*,3S*,5S*)-N,2-dimethyl-3-hydroxy-5-(10-phenyldecyl)pyrrolidine (1), and 17 known compounds were isolated from Arisaema franchetianum Engl. (Araceae) tubers. The 17 compounds were bergenin (2), emodin (3), caffeic acid (4), nobiletin (5), 3-O--d-galactopyranosyl-hederagenin 28-O--d-xylopyranosyl(16)--d-galactopyranosyl ester (6), coniferin (7), qingyangshengenin (8), methylconiferin (9), syringaresinol 4-O--d-glucopyranoside (10), gagaminine (11), perlolyrine (12), (S)-1-(1-hydroxyethyl)--carboline (13), 1-(-carboline-1-yl)-3,4,5-trihydroxy-1-pentanone (14), 1-methoxycarbonyl--carboline (15), indolo[2,3-]carbazole (16), 4-hydroxycinnamic acid methyl ester (17), and methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl] ferulate (18). The inhibitory activities of compound 1 and its N-methyl derivative (1a) against porcine respiratory and reproductive syndrome virus (PRRSV), human leukemic K562 cells, and human breast cancer MCF-7 cells were evaluated. Compounds 1 [50% inhibited concentration (IC50)=12.5 +/- 0.6M] and 1a (IC50=15.7 +/- 0.9M) were cytotoxic against K562 cells. Compound 1a also had a weak effect on PRRSV with an IC50 value of 31.9 +/- 6.0M [selectivity index (SI)=18.7]. |
| 关键词 | Araceae Arisaema Franchetianum Alkaloids C21 Steroids Porcine Respiratory And Reproductive Syndrome Virus Cytotoxicity |
| 学科领域 | Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1080/10286020.2012.723202 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000314452400011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16617 |
| 专题 | 资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China 3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China 4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Yao,Xu, Jin-Jin,Bi, Jun-Long,et al. Chemical constituents of Arisaema franchetianum tubers[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(1):71-77. |
| APA | Su, Yao.,Xu, Jin-Jin.,Bi, Jun-Long.,Wang, Yue-Hu.,Hu, Guang-Wan.,...&Long, Chun-Lin.(2013).Chemical constituents of Arisaema franchetianum tubers.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,15(1),71-77. |
| MLA | Su, Yao,et al."Chemical constituents of Arisaema franchetianum tubers".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 15.1(2013):71-77. |
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