KIB OpenIR  > 资源植物与生物技术所级重点实验室
Chemical constituents of Arisaema franchetianum tubers
Su, Yao1,2; Xu, Jin-Jin1; Bi, Jun-Long3; Wang, Yue-Hu1; Hu, Guang-Wan1; Yang, Jun1; Yin, Ge-Fen3; Long, Chun-Lin1,4
Corresponding AuthorYin, GF (reprint author), Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China. ; yingefen383@sohu.com ; long@mail.kib.ac.cn
2013
Source PublicationJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
Volume15Issue:1Pages:71-77
AbstractA novel pyrrolidine alkaloid, (2R*,3S*,5S*)-N,2-dimethyl-3-hydroxy-5-(10-phenyldecyl)pyrrolidine (1), and 17 known compounds were isolated from Arisaema franchetianum Engl. (Araceae) tubers. The 17 compounds were bergenin (2), emodin (3), caffeic acid (4), nobiletin (5), 3-O--d-galactopyranosyl-hederagenin 28-O--d-xylopyranosyl(16)--d-galactopyranosyl ester (6), coniferin (7), qingyangshengenin (8), methylconiferin (9), syringaresinol 4-O--d-glucopyranoside (10), gagaminine (11), perlolyrine (12), (S)-1-(1-hydroxyethyl)--carboline (13), 1-(-carboline-1-yl)-3,4,5-trihydroxy-1-pentanone (14), 1-methoxycarbonyl--carboline (15), indolo[2,3-]carbazole (16), 4-hydroxycinnamic acid methyl ester (17), and methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl] ferulate (18). The inhibitory activities of compound 1 and its N-methyl derivative (1a) against porcine respiratory and reproductive syndrome virus (PRRSV), human leukemic K562 cells, and human breast cancer MCF-7 cells were evaluated. Compounds 1 [50% inhibited concentration (IC50)=12.5 +/- 0.6M] and 1a (IC50=15.7 +/- 0.9M) were cytotoxic against K562 cells. Compound 1a also had a weak effect on PRRSV with an IC50 value of 31.9 +/- 6.0M [selectivity index (SI)=18.7].
KeywordAraceae Arisaema Franchetianum Alkaloids C21 Steroids Porcine Respiratory And Reproductive Syndrome Virus Cytotoxicity
Subject AreaPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1080/10286020.2012.723202
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000314452400011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16617
Collection资源植物与生物技术所级重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Su, Yao,Xu, Jin-Jin,Bi, Jun-Long,et al. Chemical constituents of Arisaema franchetianum tubers[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(1):71-77.
APA Su, Yao.,Xu, Jin-Jin.,Bi, Jun-Long.,Wang, Yue-Hu.,Hu, Guang-Wan.,...&Long, Chun-Lin.(2013).Chemical constituents of Arisaema franchetianum tubers.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,15(1),71-77.
MLA Su, Yao,et al."Chemical constituents of Arisaema franchetianum tubers".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 15.1(2013):71-77.
Files in This Item: Download All
File Name/Size DocType Version Access License
2013072909.pdf(117KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Su, Yao]'s Articles
[Xu, Jin-Jin]'s Articles
[Bi, Jun-Long]'s Articles
Baidu academic
Similar articles in Baidu academic
[Su, Yao]'s Articles
[Xu, Jin-Jin]'s Articles
[Bi, Jun-Long]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Su, Yao]'s Articles
[Xu, Jin-Jin]'s Articles
[Bi, Jun-Long]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 2013072909.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.