Chemical constituents of Arisaema franchetianum tubers
Su, Yao1,2; Xu, Jin-Jin1; Bi, Jun-Long3; Wang, Yue-Hu1; Hu, Guang-Wan1; Yang, Jun1; Yin, Ge-Fen3; Long, Chun-Lin1,4
2013
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
卷号15期号:1页码:71-77
摘要A novel pyrrolidine alkaloid, (2R*,3S*,5S*)-N,2-dimethyl-3-hydroxy-5-(10-phenyldecyl)pyrrolidine (1), and 17 known compounds were isolated from Arisaema franchetianum Engl. (Araceae) tubers. The 17 compounds were bergenin (2), emodin (3), caffeic acid (4), nobiletin (5), 3-O--d-galactopyranosyl-hederagenin 28-O--d-xylopyranosyl(16)--d-galactopyranosyl ester (6), coniferin (7), qingyangshengenin (8), methylconiferin (9), syringaresinol 4-O--d-glucopyranoside (10), gagaminine (11), perlolyrine (12), (S)-1-(1-hydroxyethyl)--carboline (13), 1-(-carboline-1-yl)-3,4,5-trihydroxy-1-pentanone (14), 1-methoxycarbonyl--carboline (15), indolo[2,3-]carbazole (16), 4-hydroxycinnamic acid methyl ester (17), and methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl] ferulate (18). The inhibitory activities of compound 1 and its N-methyl derivative (1a) against porcine respiratory and reproductive syndrome virus (PRRSV), human leukemic K562 cells, and human breast cancer MCF-7 cells were evaluated. Compounds 1 [50% inhibited concentration (IC50)=12.5 +/- 0.6M] and 1a (IC50=15.7 +/- 0.9M) were cytotoxic against K562 cells. Compound 1a also had a weak effect on PRRSV with an IC50 value of 31.9 +/- 6.0M [selectivity index (SI)=18.7].
关键词Araceae Arisaema Franchetianum Alkaloids C21 Steroids Porcine Respiratory And Reproductive Syndrome Virus Cytotoxicity
资助信息National Natural Science Foundation of China [20972166, 31160509, 31161140345, 31070288]; Yunnan Provincial Program for Excellent Scientists [2009CI125]; Key Research Direction Project of Knowledge Innovation Program for Chinese Academy of Sciences [KSCX2-EW-J-24]; Ministry of Education of China [B08044, MUC985-9, MUC98506-01000101]; National Natural Science Foundation of China(20972166; Yunnan Provincial Program for Excellent Scientists(2009CI125); Key Research Direction Project of Knowledge Innovation Program for Chinese Academy of Sciences(KSCX2-EW-J-24); Ministry of Education of China(B08044; 31160509; MUC985-9; 31161140345; MUC98506-01000101); 31070288)
学科领域Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1080/10286020.2012.723202
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000314452400011
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16617
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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Su, Yao,Xu, Jin-Jin,Bi, Jun-Long,et al. Chemical constituents of Arisaema franchetianum tubers[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(1):71-77.
APA Su, Yao.,Xu, Jin-Jin.,Bi, Jun-Long.,Wang, Yue-Hu.,Hu, Guang-Wan.,...&Long, Chun-Lin.(2013).Chemical constituents of Arisaema franchetianum tubers.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,15(1),71-77.
MLA Su, Yao,et al."Chemical constituents of Arisaema franchetianum tubers".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 15.1(2013):71-77.
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