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题名: Chemical constituents of Arisaema franchetianum tubers
作者: Su, Yao1, 2; Xu, Jin-Jin1; Bi, Jun-Long3; Wang YueHu(王跃虎)1; Hu, Guang-Wan1; Yang, Jun1; Yin, Ge-Fen3; Long, Chun-Lin1, 4
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
关键词: Araceae ; Arisaema franchetianum ; alkaloids ; C21 steroids ; porcine respiratory and reproductive syndrome virus ; cytotoxicity
英文摘要: A novel pyrrolidine alkaloid, (2R*,3S*,5S*)-N,2-dimethyl-3-hydroxy-5-(10-phenyldecyl)pyrrolidine (1), and 17 known compounds were isolated from Arisaema franchetianum Engl. (Araceae) tubers. The 17 compounds were bergenin (2), emodin (3), caffeic acid (4), nobiletin (5), 3-O--d-galactopyranosyl-hederagenin 28-O--d-xylopyranosyl(16)--d-galactopyranosyl ester (6), coniferin (7), qingyangshengenin (8), methylconiferin (9), syringaresinol 4-O--d-glucopyranoside (10), gagaminine (11), perlolyrine (12), (S)-1-(1-hydroxyethyl)--carboline (13), 1-(-carboline-1-yl)-3,4,5-trihydroxy-1-pentanone (14), 1-methoxycarbonyl--carboline (15), indolo[2,3-]carbazole (16), 4-hydroxycinnamic acid methyl ester (17), and methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl] ferulate (18). The inhibitory activities of compound 1 and its N-methyl derivative (1a) against porcine respiratory and reproductive syndrome virus (PRRSV), human leukemic K562 cells, and human breast cancer MCF-7 cells were evaluated. Compounds 1 [50% inhibited concentration (IC50)=12.5 +/- 0.6M] and 1a (IC50=15.7 +/- 0.9M) were cytotoxic against K562 cells. Compound 1a also had a weak effect on PRRSV with an IC50 value of 31.9 +/- 6.0M [selectivity index (SI)=18.7].
出版日期: 2013
卷号: 15, 期号:1, 页码:71-77
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Applied; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 1028-6020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16617
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China

Recommended Citation:
Su, Yao; Xu, Jin-Jin; Bi, Jun-Long; Wang, Yue-Hu; Hu, Guang-Wan; Yang, Jun; Yin, Ge-Fen; Long, Chun-Lin.Chemical constituents of Arisaema franchetianum tubers,JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(1):71-77
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