Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells
Zhao Zhi-fang1; Zhou Li-li1; Chen Xia1; Cheng Yong-xian2; Hou Fan-fan1; Nie Jing1
2013-04-05
发表期刊CHINESE MEDICAL JOURNAL
ISSN0366-6999
卷号126期号:7页码:1230-1235
摘要Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Various treatment regimens and combinations of therapies provide only partial renoprotection. Therefore new approaches are needed to retard the progression of DN. The aim of the present study was to evaluate the role of a novel spiroalkaloid from Acorus tatarinowii named acortatarin A (AcorA) in inhibiting high glucose-induced extracellular matrix accumulation in mesangial cells (MCs).
关键词Acortatarin a High Glucose Mesangial Cells Extracellular Matrix
资助信息National "973" Program [2012CB517700]; National Natural Science Foundation of China [U0932002]; Knowledge Innovation Program of Chinese Academy of Sciences [KSCX2-YW-R-211]; Project of Natural Compound Library Construction from Chinese Academy of Sciences [KSCX2-EW-R-15]
学科领域Medicine, General & Internal
收录类别SCI
语种英语
WOS研究方向General & Internal Medicine
WOS类目Medicine, General & Internal
WOS记录号WOS:000319783800006
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16579
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Southern Med Univ, Res Inst Nephrol Guangdong Prov, Key Lab Organ Failure Res, Div Nephrol,Nanfang Hosp,Minist Educ, Guangzhou 510515, Guangdong, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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Zhao Zhi-fang,Zhou Li-li,Chen Xia,et al. Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells[J]. CHINESE MEDICAL JOURNAL,2013,126(7):1230-1235.
APA Zhao Zhi-fang,Zhou Li-li,Chen Xia,Cheng Yong-xian,Hou Fan-fan,&Nie Jing.(2013).Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells.CHINESE MEDICAL JOURNAL,126(7),1230-1235.
MLA Zhao Zhi-fang,et al."Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells".CHINESE MEDICAL JOURNAL 126.7(2013):1230-1235.
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