Cytotoxic Bisbenzylisoquinoline Alkaloids from Stephania epigaea

	Cytotoxic Bisbenzylisoquinoline Alkaloids from Stephania epigaea
	Lv, Jun-Jiang 1,2; Xu, Min 1; Wang, Dong 1; Zhu, Hong-Tao 1; Yang, Chong-Ren 1; Wang, Yi-Fei 3; Li, Yan1 ; Zhang, Ying-Jun1
	2013-05-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	76 期号:5 页码:926-932
摘要	Six new bisberizylisoquinoline alkaloids (1-6) and seven known compounds (8-14) were isolated from the tubers of Stephania epigaea, in addition to the major alkaloid, cepharanthine (7). The structures of 1-6 were elucidated by combined spectroscopic data analysis and chemical methods, with their configurations determined from their optical rotation values and confirmed using circular dichroism. Compounds 1-6 belong to the oxyacanthine type of bisbenzylisoquinoline alkaloids and have a rare methylenedioxy substituent. Compound 1, a dimer composed of benzylisoquinoline and seco-aristolactam units, represents a new type of bisbenzylisoquinoline alkaloid, while compounds 306 are bisbenzylisoquinoline N-oxides. These compounds were evaluated for their in vitro cytotoxicities against six human cancer cell lines (A-549, ECA109, HL-60, MCF-7, SMMC-7721, and SW480). Cepharanthine (7), the major component of S. epigaea, exhibited cytotoxicity against all of these cancer cell lines except ECA109, while its known analogue, 10, displayed cytotoxicity against all six cancer cell lines.
关键词	Hayata Plants
资助信息	973 Program of Ministry of Science and Technology of China [2011CB915503]; Twelfth Five-Year National Science and Technology Support Program [2012BAI29B06]
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别	SCI ; IC
语种	英语
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000319650600016
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16549
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Lv, Jun-Jiang,Xu, Min,Wang, Dong,et al. Cytotoxic Bisbenzylisoquinoline Alkaloids from Stephania epigaea[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(5):926-932.
APA	Lv, Jun-Jiang.,Xu, Min.,Wang, Dong.,Zhu, Hong-Tao.,Yang, Chong-Ren.,...&Zhang, Ying-Jun.(2013).Cytotoxic Bisbenzylisoquinoline Alkaloids from Stephania epigaea.JOURNAL OF NATURAL PRODUCTS,76(5),926-932.
MLA	Lv, Jun-Jiang,et al."Cytotoxic Bisbenzylisoquinoline Alkaloids from Stephania epigaea".JOURNAL OF NATURAL PRODUCTS 76.5(2013):926-932.

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