Cytotoxic Bisbenzylisoquinoline Alkaloids from Stephania epigaea
Lv, Jun-Jiang1,2; Xu, Min1; Wang, Dong1; Zhu, Hong-Tao1; Yang, Chong-Ren1; Wang, Yi-Fei3; Li, Yan1; Zhang, Ying-Jun1
2013-05-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:5页码:926-932
摘要Six new bisberizylisoquinoline alkaloids (1-6) and seven known compounds (8-14) were isolated from the tubers of Stephania epigaea, in addition to the major alkaloid, cepharanthine (7). The structures of 1-6 were elucidated by combined spectroscopic data analysis and chemical methods, with their configurations determined from their optical rotation values and confirmed using circular dichroism. Compounds 1-6 belong to the oxyacanthine type of bisbenzylisoquinoline alkaloids and have a rare methylenedioxy substituent. Compound 1, a dimer composed of benzylisoquinoline and seco-aristolactam units, represents a new type of bisbenzylisoquinoline alkaloid, while compounds 306 are bisbenzylisoquinoline N-oxides. These compounds were evaluated for their in vitro cytotoxicities against six human cancer cell lines (A-549, ECA109, HL-60, MCF-7, SMMC-7721, and SW480). Cepharanthine (7), the major component of S. epigaea, exhibited cytotoxicity against all of these cancer cell lines except ECA109, while its known analogue, 10, displayed cytotoxicity against all six cancer cell lines.
关键词Hayata Plants
资助信息973 Program of Ministry of Science and Technology of China [2011CB915503]; Twelfth Five-Year National Science and Technology Support Program [2012BAI29B06]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000319650600016
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16549
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
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Lv, Jun-Jiang,Xu, Min,Wang, Dong,et al. Cytotoxic Bisbenzylisoquinoline Alkaloids from Stephania epigaea[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(5):926-932.
APA Lv, Jun-Jiang.,Xu, Min.,Wang, Dong.,Zhu, Hong-Tao.,Yang, Chong-Ren.,...&Zhang, Ying-Jun.(2013).Cytotoxic Bisbenzylisoquinoline Alkaloids from Stephania epigaea.JOURNAL OF NATURAL PRODUCTS,76(5),926-932.
MLA Lv, Jun-Jiang,et al."Cytotoxic Bisbenzylisoquinoline Alkaloids from Stephania epigaea".JOURNAL OF NATURAL PRODUCTS 76.5(2013):926-932.
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