Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia
Wang, Xiao-Ying1,2; Tang, Gui-Hua2; Yuan, Chun-Mao2; Zhang, Yu2; Zou, Tao1; Yu, Chun1; Zhao, Qing1; Hao, Xiao-Jiang; He, Hong-Ping1,2
2013-03-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号85页码:64-68
摘要Three new cycloartane triterpenoids, aphagrandinoids A-C (1-3), and a new natural product, aphagrandinoid D (4), together with a known compound, were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS techniques. Aphagrandinoid A (1), a 29-nor-cycloart triterpenoid, features with a sprio ring system at the side chain, while aphagrandinoid C (3) is a pentnortriterpenoid. Antibacterial activities of these five compounds were also evaluated. Compounds 1 and 5 showed weak antibacterial activities (MIC values: 1.57-3.13 mu g/mL) against Staphylococcus aureus, MRSA 92(#), and MRSA 98(#). (C) 2013 Elsevier B.V. All rights reserved.
关键词Aphanamixis Grandifolia Meliaceae Cycloartane Triterpenoids Antibacterial Activities
资助信息National Basic Research Program of China (973 Program) [2009CB522300, 2009CB940900]; National Natural Science Funding of China [31170332]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI047]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16453
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ TCM, Fac Pharm, Kunming 650500, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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Wang, Xiao-Ying,Tang, Gui-Hua,Yuan, Chun-Mao,et al. Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia[J]. FITOTERAPIA,2013,85:64-68.
APA Wang, Xiao-Ying.,Tang, Gui-Hua.,Yuan, Chun-Mao.,Zhang, Yu.,Zou, Tao.,...&He, Hong-Ping.(2013).Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia.FITOTERAPIA,85,64-68.
MLA Wang, Xiao-Ying,et al."Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia".FITOTERAPIA 85(2013):64-68.
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