Alkaloids from Melodinus yunnanensis
Cai, Xiang-Hai; Li, Yan; Liu, Ya-Ping; Li, Xiao-Ning; Bao, Mei-Fen; Luo, Xiao-Dong
2012-11-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号83页码:116-124
摘要Ten monoterpenoid indole alkaloids, namely meloyine, 19S-methoxytubotaiwine N-4-oxide, 16,19-epoxy-Delta(14)-vincanol, 14 beta-hydroxymeloyunine, meloyunine, Delta(14)-vincamenine N-4-oxide, 16 beta,21 beta-epoxy-vincadine, 14 beta,15 beta-20S-quebrachamine, 3-oxo-voaphylline, 2 alpha,7 alpha-dihydroxy-dihydrovoaphylline, and 32 known alkaloids were isolated from leaves and twigs of Melodious yunnanensis. Their structures were elucidated based on 1- and 2-D NMR, FTIR, UV, and MS spectroscopic data. Meloyine I showed weak cytotoxic activity against four human cancer cell lines: MCF-7 breast cancer, SMMC-7721 hepatocellular carcinoma, HL-60 myeloid leukemia, and A-549 lung cancer. (C) 2012 Elsevier Ltd. All rights reserved.
关键词Melodinus Yunnanensis Apocynaceae Monoterpenoid Indole Alkaloid Structure Elucidation Cytotoxicity
资助信息National Natural Science Foundation of China [2107298, 21172225, 31170334]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI049]; 973 Program of the Ministry of Science and Technology of P.R. China [2009CB522300]; Chinese Academy of Sciences (XiBuZhiGuang Project)
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2012.06.013
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000310421100014
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15934
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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GB/T 7714
Cai, Xiang-Hai,Li, Yan,Liu, Ya-Ping,et al. Alkaloids from Melodinus yunnanensis[J]. PHYTOCHEMISTRY,2012,83:116-124.
APA Cai, Xiang-Hai,Li, Yan,Liu, Ya-Ping,Li, Xiao-Ning,Bao, Mei-Fen,&Luo, Xiao-Dong.(2012).Alkaloids from Melodinus yunnanensis.PHYTOCHEMISTRY,83,116-124.
MLA Cai, Xiang-Hai,et al."Alkaloids from Melodinus yunnanensis".PHYTOCHEMISTRY 83(2012):116-124.
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