Three New Sesquiterpenes with Cytotoxic Activity from Dobinea delavayi
Cheng, Zhong-Quan2,3; Yang, Dan3; Ma, Qing-Yun1; Dai, Hao-Fu1; Huang, Sheng-Zhuo1; Yi, Xiang-Hui3; Zhou, Jun2; Zhao, You-Xing1
2012-11-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号78期号:17页码:1878-1880
摘要Three new sesquiterpenes dobinins A-C (1-3), together with five known compounds, were isolated from the root of Dobinea delavayi. The structures of the three new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR and MS techniques as well as by comparison of the spectral data with those of analogous compounds reported in the literatures. Compounds 1-3 were screened for antitumor activity in vitro and exhibited definite cytotoxic activity against the human tumor cell line HL-60 with IC50 levels of 8.0 x 10(-5), 4.7 x 10(-5), and 5.1 x 10(-5) M, respectively.
关键词Dobinea Delavayi Podoaceae Sesquiterpenes Anti-cancer Activity
资助信息National Nonprofit Institute Research Grant of CATAS [ITBB110301, 1630052012014]; Scientific Foundation of Education Department of Guangxi Zhuang Automous Region [201106LX694, 201203YB181]; Financial Assistance for Excellent Talents in University of Guangxi Zhuang Automous Region [2011104]; Guilin Scientific Research and Technological Development Project [20110106-2, 20120108-6]
学科领域Plant Sciences ; Medicinal ; Chemistry ; Pharmacology & Pharmacy
DOI10.1055/s-0032-1315369
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000311718900013
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15920
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Guilin Normal Coll, Dept Chem & Engn, Guilin, Peoples R China
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Cheng, Zhong-Quan,Yang, Dan,Ma, Qing-Yun,et al. Three New Sesquiterpenes with Cytotoxic Activity from Dobinea delavayi[J]. PLANTA MEDICA,2012,78(17):1878-1880.
APA Cheng, Zhong-Quan.,Yang, Dan.,Ma, Qing-Yun.,Dai, Hao-Fu.,Huang, Sheng-Zhuo.,...&Zhao, You-Xing.(2012).Three New Sesquiterpenes with Cytotoxic Activity from Dobinea delavayi.PLANTA MEDICA,78(17),1878-1880.
MLA Cheng, Zhong-Quan,et al."Three New Sesquiterpenes with Cytotoxic Activity from Dobinea delavayi".PLANTA MEDICA 78.17(2012):1878-1880.
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