Novel Dibenzo[b,e]oxepinones from the Freshwater-Derived Fungus Chaetomium sp YMF 1.02105
Shen, Kai-Ze1,2,3; Gao, Suo4; Gao, Yan-Xiu1,2,3; Wang, An-Ran1; Xu, Yao-Bo1; Sun, Rong1,2,3; Hu, Pei-Gen1; Yang, Guo-Fu1; Li, Ai-Ji1; Zhong, Dan1; Liu, Hai-Yang4; Dong, Jin-Yan1,2,3
2012-11-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号78期号:17页码:1837-1843
摘要Six new dibenzo[b,e]oxepinone metabolites, chaetones A-F (1-6), as well as three known compounds, 1-hydroxy-6-methyl-8-hydroxymethyl-xanthone (7), citreorosein (8), and emodin (9), were obtained from a freshwater-derived fungal strain Chaetomium sp. YMF 1.02105. Their structures were established on the basis of extensive spectroscopic data analysis and comparison with spectroscopic data reported. Compounds 1-6 are further additions to the small group of dibenzo[ b,e]oxepinones represented by arugosins A-H. Compounds 1-7 were tested for their cytotoxic activities against A549, Raji, HepG2, MCF-7, and HL-60 cell lines. The results showed that compound 3 had significant cytotoxicitywith IC50 values of 1.2, 1.8, 1.9, 2.3, and 1.6 mu g/mL, respectively, against the five cancer cell lines. All compounds showed modest antimicrobial activity against Staphylococcus aureus (ATCC 6538) in standard disk assays.
关键词Chaetomium Sp. Dibenzo[b Chaetomiaceae e]Oxepinone Chaetones Cytotoxicity Antimicrobial Activity
资助信息National Natural Science Foundation of China [20862019, 31270091]; Special Fund for Basic Scientific Research of Central Colleges, Southwest University [XDJK2009B029, XDJK2010C090]; Scientific Research Foundation of Southwest University [Swu10904]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15916
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Southwest Univ, Sch Life Sci, Chongqing 400715, Peoples R China
2.Yunnan Univ, Lab Conservat & Utilizat Bioresources, Chinese Minist Educ, Kunming, Peoples R China
3.Yunnan Univ, Key Lab Microbial Resources, Chinese Minist Educ, Kunming, Peoples R China
4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Heilongtan 650201, Kunming, Peoples R China
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Shen, Kai-Ze,Gao, Suo,Gao, Yan-Xiu,et al. Novel Dibenzo[b,e]oxepinones from the Freshwater-Derived Fungus Chaetomium sp YMF 1.02105[J]. PLANTA MEDICA,2012,78(17):1837-1843.
APA Shen, Kai-Ze.,Gao, Suo.,Gao, Yan-Xiu.,Wang, An-Ran.,Xu, Yao-Bo.,...&Dong, Jin-Yan.(2012).Novel Dibenzo[b,e]oxepinones from the Freshwater-Derived Fungus Chaetomium sp YMF 1.02105.PLANTA MEDICA,78(17),1837-1843.
MLA Shen, Kai-Ze,et al."Novel Dibenzo[b,e]oxepinones from the Freshwater-Derived Fungus Chaetomium sp YMF 1.02105".PLANTA MEDICA 78.17(2012):1837-1843.
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