Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation
Geng, Chang-An1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Yao, Shu-Ying1; Xue, Duo-Qing1; Zhang, Rong-Ping2; Chen, Ji-Jun1
Corresponding AuthorChen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China.,chenjj@mail.kib.ac.cn
2012-08-22
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume60Issue:33Pages:8197-8202
AbstractMulberrofuran G (1) and isomulberrofuran G (2), a pair of isomeric Diels-Alder-type adducts, were isolated from the root bark of Morus alba L. Isomulberrofuran G (2) as a new LIB-type Diels-Alder-type adduct, was elucidated by extensive H-1, C-13, and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) spectroscopic analyses. A fragmentation study on compounds 1 and 2 was performed by high-resolution electrospray ionization (ESI) multistage tandem mass spectrometry linked with ion-trap (IT) and time-of-flight (TOF) mass analyzers (ESI-MSn/IT-TOF) in negative mode, which resulted in obviously different fragmentations. In the MS2 experiments, the characteristic ions at m/z 451 and 439 could be revealed as their respective diagnostic ions. Mulberrofuran G (1) showed moderate activity, inhibiting hepatitis B virus (HBV) DNA replication with the IC50 value of 3.99 mu M, according to the anti-HBV assay on the HepG 2.2.15 cell line in vitro.
KeywordMorus Alba Isomulberrofuran g Diels-alder-type Adducts Msn Fragmentation Study Lcms-it-tof Anti-hbv Activity
DOI10.1021/jf302639b
Indexed BySCI ; IC
Language英语
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000307698900017
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15714
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
2.Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Geng, Chang-An,Ma, Yun-Bao,Zhang, Xue-Mei,et al. Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012,60(33):8197-8202.
APA Geng, Chang-An.,Ma, Yun-Bao.,Zhang, Xue-Mei.,Yao, Shu-Ying.,Xue, Duo-Qing.,...&Chen, Ji-Jun.(2012).Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,60(33),8197-8202.
MLA Geng, Chang-An,et al."Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60.33(2012):8197-8202.
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