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题名: Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation
作者: Geng, Chang-An1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Yao, Shu-Ying1; Xue, Duo-Qing1; Zhang, Rong-Ping2; null(陈纪军)1
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
关键词: Morus alba ; isomulberrofuran G ; Diels-Alder-type adducts ; MSn fragmentation study ; LCMS-IT-TOF ; anti-HBV activity
英文摘要: Mulberrofuran G (1) and isomulberrofuran G (2), a pair of isomeric Diels-Alder-type adducts, were isolated from the root bark of Morus alba L. Isomulberrofuran G (2) as a new LIB-type Diels-Alder-type adduct, was elucidated by extensive H-1, C-13, and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) spectroscopic analyses. A fragmentation study on compounds 1 and 2 was performed by high-resolution electrospray ionization (ESI) multistage tandem mass spectrometry linked with ion-trap (IT) and time-of-flight (TOF) mass analyzers (ESI-MSn/IT-TOF) in negative mode, which resulted in obviously different fragmentations. In the MS2 experiments, the characteristic ions at m/z 451 and 439 could be revealed as their respective diagnostic ions. Mulberrofuran G (1) showed moderate activity, inhibiting hepatitis B virus (HBV) DNA replication with the IC50 value of 3.99 mu M, according to the anti-HBV assay on the HepG 2.2.15 cell line in vitro.
出版日期: 2012-08-22
卷号: 60, 期号:33, 页码:8197-8202
语种: 英语
收录类别: SCI ; IC
ISSN号: 0021-8561
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15714
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
2.Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China

Recommended Citation:
Geng, Chang-An; Ma, Yun-Bao; Zhang, Xue-Mei; Yao, Shu-Ying; Xue, Duo-Qing; Zhang, Rong-Ping; Chen, Ji-Jun.Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012,60(33):8197-8202
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