| Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation | |
Geng, Chang-An1 ; Ma, Yun-Bao1; Zhang, Xue-Mei1; Yao, Shu-Ying1; Xue, Duo-Qing1; Zhang, Rong-Ping2; Chen, Ji-Jun1
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| 通讯作者 | Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China.,chenjj@mail.kib.ac.cn |
| 2012-08-22 | |
| 发表期刊 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| ISSN | 0021-8561 |
| 卷号 | 60期号:33页码:8197-8202 |
| 摘要 | Mulberrofuran G (1) and isomulberrofuran G (2), a pair of isomeric Diels-Alder-type adducts, were isolated from the root bark of Morus alba L. Isomulberrofuran G (2) as a new LIB-type Diels-Alder-type adduct, was elucidated by extensive H-1, C-13, and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) spectroscopic analyses. A fragmentation study on compounds 1 and 2 was performed by high-resolution electrospray ionization (ESI) multistage tandem mass spectrometry linked with ion-trap (IT) and time-of-flight (TOF) mass analyzers (ESI-MSn/IT-TOF) in negative mode, which resulted in obviously different fragmentations. In the MS2 experiments, the characteristic ions at m/z 451 and 439 could be revealed as their respective diagnostic ions. Mulberrofuran G (1) showed moderate activity, inhibiting hepatitis B virus (HBV) DNA replication with the IC50 value of 3.99 mu M, according to the anti-HBV assay on the HepG 2.2.15 cell line in vitro. |
| 关键词 | Morus Alba Isomulberrofuran g Diels-alder-type Adducts Msn Fragmentation Study Lcms-it-tof Anti-hbv Activity |
| DOI | 10.1021/jf302639b |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000307698900017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15714 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China 2.Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Chang-An,Ma, Yun-Bao,Zhang, Xue-Mei,et al. Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012,60(33):8197-8202. |
| APA | Geng, Chang-An.,Ma, Yun-Bao.,Zhang, Xue-Mei.,Yao, Shu-Ying.,Xue, Duo-Qing.,...&Chen, Ji-Jun.(2012).Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,60(33),8197-8202. |
| MLA | Geng, Chang-An,et al."Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60.33(2012):8197-8202. |
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