Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation
Geng, Chang-An1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Yao, Shu-Ying1; Xue, Duo-Qing1; Zhang, Rong-Ping2; Chen, Ji-Jun1
2012-08-22
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
卷号60期号:33页码:8197-8202
摘要Mulberrofuran G (1) and isomulberrofuran G (2), a pair of isomeric Diels-Alder-type adducts, were isolated from the root bark of Morus alba L. Isomulberrofuran G (2) as a new LIB-type Diels-Alder-type adduct, was elucidated by extensive H-1, C-13, and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) spectroscopic analyses. A fragmentation study on compounds 1 and 2 was performed by high-resolution electrospray ionization (ESI) multistage tandem mass spectrometry linked with ion-trap (IT) and time-of-flight (TOF) mass analyzers (ESI-MSn/IT-TOF) in negative mode, which resulted in obviously different fragmentations. In the MS2 experiments, the characteristic ions at m/z 451 and 439 could be revealed as their respective diagnostic ions. Mulberrofuran G (1) showed moderate activity, inhibiting hepatitis B virus (HBV) DNA replication with the IC50 value of 3.99 mu M, according to the anti-HBV assay on the HepG 2.2.15 cell line in vitro.
关键词Morus Alba Isomulberrofuran g Diels-alder-type Adducts Msn Fragmentation Study Lcms-it-tof Anti-hbv Activity
资助信息National Science Foundation of China for Distinguished Young Scholars [81025023]
DOI10.1021/jf302639b
收录类别SCI ; IC
语种英语
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
WOS类目Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS记录号WOS:000307698900017
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15714
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
2.Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China
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Geng, Chang-An,Ma, Yun-Bao,Zhang, Xue-Mei,et al. Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012,60(33):8197-8202.
APA Geng, Chang-An.,Ma, Yun-Bao.,Zhang, Xue-Mei.,Yao, Shu-Ying.,Xue, Duo-Qing.,...&Chen, Ji-Jun.(2012).Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,60(33),8197-8202.
MLA Geng, Chang-An,et al."Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60.33(2012):8197-8202.
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