Two new compounds and anti-HIV active constituents from Illicium verum

doi:10.1055/s-2007-967162

	Two new compounds and anti-HIV active constituents from Illicium verum
	Song, Wen-Yong ; Ma, Yun-Bao ; Bai, Xue ; Zhang, Xue-Mei; Gu, Qiong ; Zheng, Yong-Tang ; Zhou, Jun; Chen, Ji-Jun
	2007-04-01
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	73 期号:4 页码:372-375
摘要	Two new compounds named illiverin A (1) and tashironin A (8) were, isolated from the roots of Illicium verum, together with seven known compounds: 4-allyl-2-(3-methylbut-2-enyl)-1,6-methylenedioxybenzene-3-ol (2), illicinole (3), 3-hydroxy-4,5-methylenedioxyallyl-benzene (4),(-)-illicinone-A (5), 4-allyl-4-(3-methylbut-2-enyl)-1,2-methylenedioxycyclohexa-2,6-dien-5-one (6), 3,4-seco-(24Z)- cycloart-4(28),24-diene-3,26-dioic acid, 26-methyl ester (7)and tashironin (9). Based on 1D- and 2D-NMR data (COSY, HMQC, HMBC), the structures of the new compounds were deduced to be (E)-1-[(3-methylbut-2-enyl)oxy]-2-methoxy-4-(prop-1-enyl)benzene (1) and 11-O-2-debenzoyl-11 alpha-O-2-methylcyclopent-1- enecarboxyltashironin (8). Compounds 1 - 9 were screened for anti-HIV activity in vitro whereby compounds 5 and 7 possessed moderate anti-HIV activity with EC50 values of 16.0 and 5.1 mu M with SI values of 18.2 and 15.6, respectively.
关键词	Tashiroi Maxim Sesquiterpenes Phytoquinoids Merrillianum Components Fruits Plants
学科领域	Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI	10.1055/s-2007-967162
收录类别	SCI
语种	英语
WOS记录号	WOS:000246690600012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1541
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650204, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Branch, Joint Lab Antiviral Nat Med, Kunming 650204, Yunnan, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Song, Wen-Yong,Ma, Yun-Bao,Bai, Xue,et al. Two new compounds and anti-HIV active constituents from Illicium verum[J]. PLANTA MEDICA,2007,73(4):372-375.
APA	Song, Wen-Yong.,Ma, Yun-Bao.,Bai, Xue.,Zhang, Xue-Mei.,Gu, Qiong.,...&Chen, Ji-Jun.(2007).Two new compounds and anti-HIV active constituents from Illicium verum.PLANTA MEDICA,73(4),372-375.
MLA	Song, Wen-Yong,et al."Two new compounds and anti-HIV active constituents from Illicium verum".PLANTA MEDICA 73.4(2007):372-375.

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