Two new compounds and anti-HIV active constituents from Illicium verum
Song, Wen-Yong; Ma, Yun-Bao; Bai, Xue; Zhang, Xue-Mei; Gu, Qiong; Zheng, Yong-Tang; Zhou, Jun; Chen, Ji-Jun
2007-04-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号73期号:4页码:372-375
摘要Two new compounds named illiverin A (1) and tashironin A (8) were, isolated from the roots of Illicium verum, together with seven known compounds: 4-allyl-2-(3-methylbut-2-enyl)-1,6-methylenedioxybenzene-3-ol (2), illicinole (3), 3-hydroxy-4,5-methylenedioxyallyl-benzene (4),(-)-illicinone-A (5), 4-allyl-4-(3-methylbut-2-enyl)-1,2-methylenedioxycyclohexa-2,6-dien-5-one (6), 3,4-seco-(24Z)- cycloart-4(28),24-diene-3,26-dioic acid, 26-methyl ester (7)and tashironin (9). Based on 1D- and 2D-NMR data (COSY, HMQC, HMBC), the structures of the new compounds were deduced to be (E)-1-[(3-methylbut-2-enyl)oxy]-2-methoxy-4-(prop-1-enyl)benzene (1) and 11-O-2-debenzoyl-11 alpha-O-2-methylcyclopent-1- enecarboxyltashironin (8). Compounds 1 - 9 were screened for anti-HIV activity in vitro whereby compounds 5 and 7 possessed moderate anti-HIV activity with EC50 values of 16.0 and 5.1 mu M with SI values of 18.2 and 15.6, respectively.
关键词Tashiroi Maxim Sesquiterpenes Phytoquinoids Merrillianum Components Fruits Plants
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1541
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650204, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Branch, Joint Lab Antiviral Nat Med, Kunming 650204, Yunnan, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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Song, Wen-Yong,Ma, Yun-Bao,Bai, Xue,et al. Two new compounds and anti-HIV active constituents from Illicium verum[J]. PLANTA MEDICA,2007,73(4):372-375.
APA Song, Wen-Yong.,Ma, Yun-Bao.,Bai, Xue.,Zhang, Xue-Mei.,Gu, Qiong.,...&Chen, Ji-Jun.(2007).Two new compounds and anti-HIV active constituents from Illicium verum.PLANTA MEDICA,73(4),372-375.
MLA Song, Wen-Yong,et al."Two new compounds and anti-HIV active constituents from Illicium verum".PLANTA MEDICA 73.4(2007):372-375.
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