In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells

	In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells
	Taechowisan, Thongchai ; Lu, Chunhua ; Shen, Yuemao ; Lumyong, Saisamorn
通讯作者	Taechowisan, T (reprint author), Silpakorn Univ, Fac Sci, Dept Microbiol, Nakhon Pathom 73000, Thailand. tthongch@su.ac.th
	2007
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	21 期号:12 页码:1104-1113
摘要	This research was undertaken to find the in vitro inflammatory action of 5,7-dimethoxy4- p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of nitric oxide (NO), PGE(2), TNF-alpha, IL-6 and IL-1 beta, but also on inducible NO synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced PGE2 release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha. These findings support the application of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin as anti-inflammatory agents.
关键词	4-arylcoumarins Anti-inflammatory Activity Endophytic Streptomyces Murine Macrophage Raw 264.7 Cells Human-leukocyte Elastase Coumarin Derivatives Antifungal Activity Inhibitors Lipopolysaccharide Cyclooxygenase-2 Inflammation Enzyme Acid
学科领域	Chemistry, Applied ; Chemistry, Medicinal
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/15416
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,et al. In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells[J]. NATURAL PRODUCT RESEARCH,2007,21(12):1104-1113.
APA	Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,&Lumyong, Saisamorn.(2007).In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells.NATURAL PRODUCT RESEARCH,21(12),1104-1113.
MLA	Taechowisan, Thongchai,et al."In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells".NATURAL PRODUCT RESEARCH 21.12(2007):1104-1113.

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