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题名: In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells
作者: Taechowisan, Thongchai ; Lu, Chunhua ; Shen, Yuemao ; Lumyong, Saisamorn
刊名: NATURAL PRODUCT RESEARCH
关键词: 4-arylcoumarins ; anti-inflammatory activity ; endophytic streptomyces ; murine macrophage RAW 264.7 cells ; HUMAN-LEUKOCYTE ELASTASE ; COUMARIN DERIVATIVES ; ANTIFUNGAL ACTIVITY ; INHIBITORS ; LIPOPOLYSACCHARIDE ; CYCLOOXYGENASE-2 ; INFLAMMATION ; ENZYME ; ACID
英文摘要: This research was undertaken to find the in vitro inflammatory action of 5,7-dimethoxy4- p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of nitric oxide (NO), PGE(2), TNF-alpha, IL-6 and IL-1 beta, but also on inducible NO synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced PGE2 release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha. These findings support the application of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin as anti-inflammatory agents.
出版日期: 2007
卷号: 21, 期号:12, 页码:1104-1113
语种: 英语
ISSN号: 1478-6419
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15416
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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Recommended Citation:
Taechowisan, Thongchai; Lu, Chunhua; Shen, Yuemao; Lumyong, Saisamorn.In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells,NATURAL PRODUCT RESEARCH,2007,21(12):1104-1113
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