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题名: Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus
作者: Weng, Zhi-Ying; null(黄胜雄); Li, Ma-Lin; Zeng, Yue-Qin; Han, Quan-Bin; Rios, Jose Luis; null(孙汉董)
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
关键词: anti-inflammation ; cytotoxicity ; herbal tea ; Isodon xerophilus ; ent-kaurene diterpenoid
英文摘要: Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I. xerophilus leaves led to the isolation of two new ent-kauranoids, xerophinoids A (1) and B (2), together with 14 known diterpenoids. The structures of xerophinoids A (1) and B (2) were illustrated using spectroscopic methods including 1D and 2D NMR analyses. To study their biological activities, the effects of xerophinoids A (1) and B (2) on nitrite production, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta were examined. In addition, xerophinoids A (1) and B (2) also exhibited potent cytotoxicity against several human tumor cell lines (IC(50) < 11 mu M), but they had no toxicity on human T-lymphocyte (C8166).
出版日期: 2007-07-26
卷号: 55, 期号:15, 页码:6039-6043
DOI标识: 10.1021/jf070734w
语种: 英语
ISSN号: 0021-8561
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15406
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Coll Med, Yunnan Lab Pharmacol Nat Prod, Kunming 650031, Peoples R China
4.Univ Valencia, Dept Pharmacol, E-46100 Burjassot, Spain

Recommended Citation:
Weng, Zhi-Ying; Huang, Sheng-Xiong; Li, Ma-Lin; Zeng, Yue-Qin; Han, Quan-Bin; Rios, Jose Luis; Sun, Han-Dong.Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2007,55(15):6039-6043
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