Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus
Weng, Zhi-Ying; Huang, Sheng-Xiong; Li, Ma-Lin; Zeng, Yue-Qin; Han, Quan-Bin; Rios, Jose Luis; Sun, Han-Dong
2007-07-26
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
卷号55期号:15页码:6039-6043
摘要Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I. xerophilus leaves led to the isolation of two new ent-kauranoids, xerophinoids A (1) and B (2), together with 14 known diterpenoids. The structures of xerophinoids A (1) and B (2) were illustrated using spectroscopic methods including 1D and 2D NMR analyses. To study their biological activities, the effects of xerophinoids A (1) and B (2) on nitrite production, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta were examined. In addition, xerophinoids A (1) and B (2) also exhibited potent cytotoxicity against several human tumor cell lines (IC(50) < 11 mu M), but they had no toxicity on human T-lymphocyte (C8166).
关键词Anti-inflammation Cytotoxicity Herbal Tea Isodon Xerophilus Ent-kaurene Diterpenoid
学科领域Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
DOI10.1021/jf070734w
收录类别SCI ; IC
语种英语
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
WOS类目Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS记录号WOS:000248085300022
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15406
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Coll Med, Yunnan Lab Pharmacol Nat Prod, Kunming 650031, Peoples R China
4.Univ Valencia, Dept Pharmacol, E-46100 Burjassot, Spain
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Weng, Zhi-Ying,Huang, Sheng-Xiong,Li, Ma-Lin,et al. Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2007,55(15):6039-6043.
APA Weng, Zhi-Ying.,Huang, Sheng-Xiong.,Li, Ma-Lin.,Zeng, Yue-Qin.,Han, Quan-Bin.,...&Sun, Han-Dong.(2007).Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,55(15),6039-6043.
MLA Weng, Zhi-Ying,et al."Isolation of two bioactive ent-Kauranoids from the leaves of Isodon xerophilus".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 55.15(2007):6039-6043.
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