Anti-inflammatory activity of lansais from endophytic Streptomyces sp SUC1 in LPS-induced RAW 264.7 cells
Taechowisan, Thongchai ; Wanbanjob, Asawin ; Tuntiwachwuttikul, Pittaya ; Liu, Jikai
2009
发表期刊FOOD AND AGRICULTURAL IMMUNOLOGY
ISSN0954-0105
卷号20期号:1页码:67-77
摘要This research was undertaken to find the in vitro inflammatory action of lansai A-D produced by Streptomyces sp. SUC1. We investigated the effects of lansai C not only on the formation of nitric oxide (NO), prostaglandin E2 (PGE2), tumour necrosis factor (TNF-), interleukin (IL)-1, IL-6 and IL-10, but also on inducible NO synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of inducible nitric oxide synthase enzyme expression. A similar fashion was also observed when LPS-induced PGE2 release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, lansai C also mildly but significantly reduced the formation of TNF-. These findings support the application of lansai C as anti-inflammatory agent.
关键词Anti-inflammatory Activity Endophytic Streptomyces Lansai c Raw 264 7 Cells Nitric-oxide Production Macrophages Lipopolysaccharide Cyclooxygenase-2 Inflammation Cytokines Pain
资助信息Thailand Research Fund[MRG5180173]
学科领域Chemistry, Applied ; Food Science & Technology ; Immunology ; Toxicology
收录类别sci
语种英语
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15378
专题植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,et al. Anti-inflammatory activity of lansais from endophytic Streptomyces sp SUC1 in LPS-induced RAW 264.7 cells[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2009,20(1):67-77.
APA Taechowisan, Thongchai,Wanbanjob, Asawin,Tuntiwachwuttikul, Pittaya,&Liu, Jikai.(2009).Anti-inflammatory activity of lansais from endophytic Streptomyces sp SUC1 in LPS-induced RAW 264.7 cells.FOOD AND AGRICULTURAL IMMUNOLOGY,20(1),67-77.
MLA Taechowisan, Thongchai,et al."Anti-inflammatory activity of lansais from endophytic Streptomyces sp SUC1 in LPS-induced RAW 264.7 cells".FOOD AND AGRICULTURAL IMMUNOLOGY 20.1(2009):67-77.
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