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题名: A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis
作者: Gu, Qiong; Wang, Rui-Rui; Zhang, Xue-Mei; Wang, Yun-Hua; Zheng, Yong-Tang; Zhou, Jun; null(陈纪军)
刊名: PLANTA MEDICA
关键词: ACID-DERIVATIVES ; BETULINIC ACID ; AIDS AGENTS ; TRITERPENES ; INHIBITORS
英文摘要: A new benzofuran lactone, rhuscholide A (1), was isolated from the stems of Rhus chinensis, together with six known compounds: 5-hydroxy-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11 tetraenyl)-2(3H)-benzofuranone (2), betulin (3), betulonic acid (4), moronic acid (5), 3-oxo-60-hydroxyolean-12-en-28-oic acid (6) and 3-oxo-60-hydroxyolean-18-en-28-oic acid (7). Based on 1D, 2D NMR (COSY, HMQC, HMBC) and mass (EI-MS, HR-EI-MS) spectral data, the structure of rhuscholide A was deduced to be 5-hydroxy-3-(propan-2-ylidene)-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11-tetraenyl)-2(3H)-benzofuranone (1). Anti-HIV-1 bioassays in vitro revealed that compound 1 possesses significant anti-HIV-1 activity with an EC50 value of 1.62 mu M and a therapeutic index (TI) of 42.40. Compounds 2, 4, 5 and 7 showed moderate anti-HIV-1 activities with EC50 values of 3.70, 5.81, 7.49 and 13.11 mu M, respectively.
出版日期: 2007-03-01
卷号: 73, 期号:3, 页码:279-282
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry; Medicinal; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1525
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Lab Mol Immunopharmacol, Key Lab Anim Models & Human Dis Mech, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Kunming Branch, Joint Lab Anti Viral Nat Med, Kunming, Peoples R China
4.Chinese Acad Sci, Grad Sch, Kunming, Peoples R China

Recommended Citation:
Gu, Q; Wang, RR; Zhang, XM; Wang, YH; Zheng, YT; Zhou, J; Chen, JJ.A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis,PLANTA MEDICA,2007,73(3):279-282
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