A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis
Gu, Qiong; Wang, Rui-Rui; Zhang, Xue-Mei; Wang, Yun-Hua; Zheng, Yong-Tang; Zhou, Jun; Chen, Ji-Jun
2007-03-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号73期号:3页码:279-282
摘要A new benzofuran lactone, rhuscholide A (1), was isolated from the stems of Rhus chinensis, together with six known compounds: 5-hydroxy-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11 tetraenyl)-2(3H)-benzofuranone (2), betulin (3), betulonic acid (4), moronic acid (5), 3-oxo-60-hydroxyolean-12-en-28-oic acid (6) and 3-oxo-60-hydroxyolean-18-en-28-oic acid (7). Based on 1D, 2D NMR (COSY, HMQC, HMBC) and mass (EI-MS, HR-EI-MS) spectral data, the structure of rhuscholide A was deduced to be 5-hydroxy-3-(propan-2-ylidene)-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11-tetraenyl)-2(3H)-benzofuranone (1). Anti-HIV-1 bioassays in vitro revealed that compound 1 possesses significant anti-HIV-1 activity with an EC50 value of 1.62 mu M and a therapeutic index (TI) of 42.40. Compounds 2, 4, 5 and 7 showed moderate anti-HIV-1 activities with EC50 values of 3.70, 5.81, 7.49 and 13.11 mu M, respectively.
关键词Acid-derivatives Betulinic Acid Aids Agents Triterpenes Inhibitors
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1525
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Lab Mol Immunopharmacol, Key Lab Anim Models & Human Dis Mech, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Kunming Branch, Joint Lab Anti Viral Nat Med, Kunming, Peoples R China
4.Chinese Acad Sci, Grad Sch, Kunming, Peoples R China
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Gu, Qiong,Wang, Rui-Rui,Zhang, Xue-Mei,et al. A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis[J]. PLANTA MEDICA,2007,73(3):279-282.
APA Gu, Qiong.,Wang, Rui-Rui.,Zhang, Xue-Mei.,Wang, Yun-Hua.,Zheng, Yong-Tang.,...&Chen, Ji-Jun.(2007).A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis.PLANTA MEDICA,73(3),279-282.
MLA Gu, Qiong,et al."A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis".PLANTA MEDICA 73.3(2007):279-282.
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