| Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents | |
Liu, Jing-Ping1,2,3; Zhang, Hong-Bin1; Huang, Sheng-Xiong2 ; Pu, Jian-Xin2; Xiao, Wei-Lie2; Zhang, Xue-Ping1; Xiao, Wen-Ding1; Lei, Chun2; Sun, Han-Dong2
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| 通讯作者 | Zhang, HB (reprint author), Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China. ; Zhang, HB (reprint author), Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China. ; zhanghb@ynu.edu.cn ; zhanghb@ynu.edu.cn ; hdsun@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 2012-05-01 | |
| 发表期刊 | JOURNAL OF HETEROCYCLIC CHEMISTRY
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| ISSN | 0022-152X ; 0022-152X |
| 卷号 | 49期号:3页码:571-575 |
| 摘要 | Laxiflorin J, isolated from the leaves of Isodon eriocalyx var. laxiflora, showed significant inhibitory activity toward T-24 cells. A series of laxiflorin J derivatives were synthesized and their in vitro activity was evaluated against BEL-7402, A-549, HT-29, HL-60, MOLT-4 tumor cell lines, with IC50 values ranging from 1.3 to 42.2 mu g mL-1. |
| 关键词 | #name #name |
| 学科领域 | Chemistry, Organic ; Chemistry, Organic |
| DOI | 10.1002/jhet.816 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000306312700015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15097 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Yunnan Normal Univ, Dept Chem, Kunming 650092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jing-Ping,Zhang, Hong-Bin,Huang, Sheng-Xiong,et al. Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2012,49(3):571-575. |
| APA | Liu, Jing-Ping.,Zhang, Hong-Bin.,Huang, Sheng-Xiong.,Pu, Jian-Xin.,Xiao, Wei-Lie.,...&Sun, Han-Dong.(2012).Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents.JOURNAL OF HETEROCYCLIC CHEMISTRY,49(3),571-575. |
| MLA | Liu, Jing-Ping,et al."Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents".JOURNAL OF HETEROCYCLIC CHEMISTRY 49.3(2012):571-575. |
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