Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents
Liu, Jing-Ping1,2,3; Zhang, Hong-Bin1; Huang, Sheng-Xiong2; Pu, Jian-Xin2; Xiao, Wei-Lie2; Zhang, Xue-Ping1; Xiao, Wen-Ding1; Lei, Chun2; Sun, Han-Dong2
2012-05-01
发表期刊JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN0022-152X ; 0022-152X
卷号49期号:3页码:571-575
摘要Laxiflorin J, isolated from the leaves of Isodon eriocalyx var. laxiflora, showed significant inhibitory activity toward T-24 cells. A series of laxiflorin J derivatives were synthesized and their in vitro activity was evaluated against BEL-7402, A-549, HT-29, HL-60, MOLT-4 tumor cell lines, with IC50 values ranging from 1.3 to 42.2 mu g mL-1.
关键词#name #name
资助信息Science Foundation of Yunnan Province Office of Education[2010Z084]; Natural Science Foundation of China[20832005]; Science Foundation of Yunnan Province Office of Education[2010Z084]; Natural Science Foundation of China[20832005]
收录类别SCI ; IC
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15097
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Yunnan Normal Univ, Dept Chem, Kunming 650092, Peoples R China
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Liu, Jing-Ping,Zhang, Hong-Bin,Huang, Sheng-Xiong,et al. Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2012,49(3):571-575.
APA Liu, Jing-Ping.,Zhang, Hong-Bin.,Huang, Sheng-Xiong.,Pu, Jian-Xin.,Xiao, Wei-Lie.,...&Sun, Han-Dong.(2012).Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents.JOURNAL OF HETEROCYCLIC CHEMISTRY,49(3),571-575.
MLA Liu, Jing-Ping,et al."Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents".JOURNAL OF HETEROCYCLIC CHEMISTRY 49.3(2012):571-575.
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