New Minor Spirostane Glycosides from Ypsilandra thibetica
Zhang, Xu-Dong1,2; Chen, Chang-Xiang1; Yang, Jun-Yun1; Ni, Wei1; Liu, Hai-Yang1
2012-07-01
发表期刊HELVETICA CHIMICA ACTA
ISSN0018-019X
卷号95期号:7页码:1087-1093
摘要A further phytochemical investigation on the whole plants of Ypsilandra thibetica yielded three new spirostane glycosides, named ypsilandrosides MO (13). Their structures were established as (3 beta,11a,25R)-3,11-dihydroxyspirost-5-en-12-one 3-{O-a-L-rhanmopyranosyl-(1?4)-O-L-rhanmopyranosyl-(1?4)-O-[a-L-rhanmopyranosyl-(1?2)]-beta-D-glucopyranoside} (1), (3 beta,7 beta,25R)-spirost-5-ene-3,7-diol 3-{O-a-L-rhanmopyranosyl-(1?4)-O-a-L-rhanmopyranosyl-(1?4)-O-[a-L-rhanmopyranosyl-(1?2)]-beta-D-glucopyranoside} (2), and (3 beta,7a,25R)-spirost-5-ene-3,7,17-triol 3-{O-a-L-rhanmopyranosyl-(1?4)-O-a-L-rhanmopyranosyl-(1?4)-O-[a-L-rhanmopyranosyl-(1?2)]-beta-D-glucopyranoside} (3) by means of a combination of MS, 1D- and 2D-NMR spectroscopic methods, and chemical degradation. Among them, compound 3 is the first pennogenin (=(3 beta,25R)-spirost-5-ene-3,17-diol) saponin whose aglycone contains an OH group at C(7). Compounds 13 were evaluated for the inhibition of the growth of five tumor cell lines, but all of them proved to be inactive.
关键词Ypsilandra Thibetica YpsilandrM?-?osides m?-?M?-?o Spirostanes Glycosides
资助信息National Natural Science Funding of China[31170333]; Natural Science Foundation of Yunnan Province[2009CC019]; West Light Foundation of the Chinese Academy of Sciences[2908025712W1]; State Key Laboratory of Phytochemistry and Plant Resources in West China[540806321211]; Germplasm Bank of Wild Species and CAS Innovation Program of the Kunming Institute of Botany
学科领域Chemistry, Multidisciplinary
DOI10.1002/hlca.201100368
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000306277000005
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15091
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China
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Zhang, Xu-Dong,Chen, Chang-Xiang,Yang, Jun-Yun,et al. New Minor Spirostane Glycosides from Ypsilandra thibetica[J]. HELVETICA CHIMICA ACTA,2012,95(7):1087-1093.
APA Zhang, Xu-Dong,Chen, Chang-Xiang,Yang, Jun-Yun,Ni, Wei,&Liu, Hai-Yang.(2012).New Minor Spirostane Glycosides from Ypsilandra thibetica.HELVETICA CHIMICA ACTA,95(7),1087-1093.
MLA Zhang, Xu-Dong,et al."New Minor Spirostane Glycosides from Ypsilandra thibetica".HELVETICA CHIMICA ACTA 95.7(2012):1087-1093.
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