Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals
Zhang, Ling1,4; Luo, Rong-Hua2,3; Wang, Fei1; Dong, Ze-Jun1; Yang, Liu-Meng2,3; Zheng, Yong-Tang2,3; Liu, Ji-Kai1
2010-11-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号71期号:16页码:1879-1883
摘要Four highly oxygenated daphnane diterpenoids, trigonothyrins D-G (1-4), were isolated from the stems of Trigonostemon thyrsoideum, and their structures were elucidated on the basis of extensive spectroscopic studies. Inhibitory activity against HIV-1 was assessed for compounds 1,3 and 4, wherein, 3 showed activity with an EC(50) value of 0.13 mu g/mL and a therapeutic index (TI) of 75.1. (C) 2010 Elsevier Ltd. All rights reserved.
关键词Trigonostemon Thyrsoideum Euphorbiaceae Daphnane Diterpenoids Trigonothyrins D-g Anti-hiv-1
资助信息National Natural Science Foundation of China [30830113]; National Basic Research Program of China (973 Program) [2009CB522300]; [2009ZX09501-029]; [2009ZX09501-013]
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2010.08.008
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000283909200008
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1505
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Zhang, Ling,Luo, Rong-Hua,Wang, Fei,et al. Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals[J]. PHYTOCHEMISTRY,2010,71(16):1879-1883.
APA Zhang, Ling.,Luo, Rong-Hua.,Wang, Fei.,Dong, Ze-Jun.,Yang, Liu-Meng.,...&Liu, Ji-Kai.(2010).Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals.PHYTOCHEMISTRY,71(16),1879-1883.
MLA Zhang, Ling,et al."Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals".PHYTOCHEMISTRY 71.16(2010):1879-1883.
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