Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals
Zhang, Ling1,4; Luo, Rong-Hua2,3; Wang, Fei1; Dong, Ze-Jun1; Yang, Liu-Meng2,3; Zheng, Yong-Tang2,3; Liu, Ji-Kai1
2010-11-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume71Issue:16Pages:1879-1883
AbstractFour highly oxygenated daphnane diterpenoids, trigonothyrins D-G (1-4), were isolated from the stems of Trigonostemon thyrsoideum, and their structures were elucidated on the basis of extensive spectroscopic studies. Inhibitory activity against HIV-1 was assessed for compounds 1,3 and 4, wherein, 3 showed activity with an EC(50) value of 0.13 mu g/mL and a therapeutic index (TI) of 75.1. (C) 2010 Elsevier Ltd. All rights reserved.
KeywordTrigonostemon Thyrsoideum Euphorbiaceae Daphnane Diterpenoids Trigonothyrins D-g Anti-hiv-1
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2010.08.008
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000283909200008
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/1505
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ling,Luo, Rong-Hua,Wang, Fei,et al. Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals[J]. PHYTOCHEMISTRY,2010,71(16):1879-1883.
APA Zhang, Ling.,Luo, Rong-Hua.,Wang, Fei.,Dong, Ze-Jun.,Yang, Liu-Meng.,...&Liu, Ji-Kai.(2010).Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals.PHYTOCHEMISTRY,71(16),1879-1883.
MLA Zhang, Ling,et al."Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals".PHYTOCHEMISTRY 71.16(2010):1879-1883.
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