Effect of total phenolics from Laggera alata on acute and chronic inflammation models
Wu, Yihang; Zhou, Changxin; Song, Liyan; Li, Xiangping; Shi, Shuyun; Mo, Jianxia; Chen, Haiyong; Bai, Hua; Wu, Xiumei; Zhao, Jun; Zhang, Rongping; Hao, Xiaojiang; Sun, Handong; Zhao, Yu
2006-11-24
发表期刊JOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
卷号108期号:2页码:243-250
摘要The anti-inflammatory effect of total phenolics from Laggera alata (TPLA) was evaluated with various in vivo models of both acute and chronic inflammations. In the acute inflammation tests, TPLA inhibited significantly xylene-induced mouse ear oedema, carrageenan-induced rat paw oedema and acetic acid-induced mouse vascular permeability. In the carrageenan-induced rat pleurisy model, TPLA significantly suppressed inflammatory exudate and leukocyte migration, reduced the serum levels of lysozyme (LZM) and malondialdehyde (MDA), increased the serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and also decreased the contents of total protein, nitric oxide (NO) and prostaglandin E-2 (PGE(2)) in the pleural exudates. In the chronic inflammation experiment, TPLA inhibited significantly cotton pellet-induced rat granuloma. These results indicated that TPLA possesses potent anti-inflammatory activity on acute and chronic inflammation models. Its anti-inflammatory mechanisms are probably associated with the inhibition of prostaglandin formation, the influence on the antioxidant systems, and the suppression of LZM release. Furthermore, the total phenolic content of Laggera alata and its main component type was quantified, and its principle components were isolated and authenticated. Acute toxicity studies revealed that TPLA up to an oral dose of 8.5 g/kg body weight was almost nontoxic in mice. (c) 2006 Published by Elsevier Ireland Ltd.
关键词Laggera Alata Folk Medicine Anti-inflammation Total Phenolics
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1479
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China
2.Zhejiang Hisun Naturelite Pharmaceut R&D Co Ltd, Hangzhou 310006, Peoples R China
3.Kunming Med Coll, Dept Pharm, Kunming 650031, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem, Kunming 650204, Peoples R China
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Wu, Yihang,Zhou, Changxin,Song, Liyan,et al. Effect of total phenolics from Laggera alata on acute and chronic inflammation models[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,108(2):243-250.
APA Wu, Yihang.,Zhou, Changxin.,Song, Liyan.,Li, Xiangping.,Shi, Shuyun.,...&Zhao, Yu.(2006).Effect of total phenolics from Laggera alata on acute and chronic inflammation models.JOURNAL OF ETHNOPHARMACOLOGY,108(2),243-250.
MLA Wu, Yihang,et al."Effect of total phenolics from Laggera alata on acute and chronic inflammation models".JOURNAL OF ETHNOPHARMACOLOGY 108.2(2006):243-250.
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