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Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：308/50  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Effect of total phenolics from Laggera alata on acute and chronic inflammation models 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2006, 卷号: 108, 期号: 2, 页码: 243-250
作者:  Wu, Yihang;  Zhou, Changxin;  Song, Liyan;  Li, Xiangping;  Shi, Shuyun;  Mo, Jianxia;  Chen, Haiyong;  Bai, Hua;  Wu, Xiumei;  Zhao, Jun;  Zhang, Rongping;  Hao, Xiaojiang;  Sun, Handong;  Zhao, Yu
Adobe PDF(343Kb)  |  收藏  |  浏览/下载：424/203  |  提交时间：2011/11/24
Laggera Alata  Folk Medicine  Anti-inflammation  Total Phenolics  
Molecular authentication of the traditional Tibetan medicinal plant Swertia mussotii 期刊论文
PLANTA MEDICA, 2006, 卷号: 72, 期号: 13, 页码: 1223-1226
作者:  Xue, Chun-Ying;  Li, De-Zhu;  Lu, Jin-Mei;  Yang, Jun-Bo;  Liu, Jian-Quan
Adobe PDF(871Kb)  |  收藏  |  浏览/下载：498/94  |  提交时间：2011/12/06
Tibetan Folk Medicine  Swertia Mussotii  Gentianaceae  Dna Sequences  Allele-specific Diagnostic Pcr  Authentication