Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A
Wei, TT; Sun, HD; Zhao, XY; Hou, JW; Hou, AJ; Zhao, QS; Xin, WJ
2002-03-08
发表期刊LIFE SCIENCES
卷号70期号:16页码:1889-1899
摘要Pistafolia A is a novel gallotannin isolated from the leaf extract of Pastacia weinmannifolia. In the present investigation, the ability of Pistafolia A to scavenge reactive oxygen species including hydroxyl radicals and superoxide anion was treasured by ESR spin trapping technique. The inhibition effect on iron-induced lipid peroxidaiton in liposomes was studied. The protective effects of Pistafolia A against oxidative neuronal cell damage and apoptosis induced by peroxynitrite were also assessed. The results showed that Pistafolia A could scavenge both hydroxyl radicals and superoxide anion dose-dependently and inhibit lipid peroxidation effectively. In cerebellar granule cells pretreated with Pistafolia A, peroxynitrite-induced oxidative neuronal damage and apoptosis were prevented markedly. The antioxidant capacity of Pistafolia A was much more potent then that of the water-soluble analog of vitamin E, Trolox. The results suggested that Pistafolia A might be used as an effective natural antioxidant for the prevention and cure of neuronal diseases associated with the production of peroxynitrite and related reactive oxygen species. (C) 2002 Elsevier Science Inc. All rights reserved.
关键词Pistafolia a Gallotannin Free Radical Cerebellar Granule Cell Oxidative Stress Apoptosis
学科领域Medicine, Research & Experimental ; Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS记录号WOS:000174822100005
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14607
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Inst Biophys, Dept Mol & Cellular Biophys, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
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Wei, TT,Sun, HD,Zhao, XY,et al. Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A[J]. LIFE SCIENCES,2002,70(16):1889-1899.
APA Wei, TT.,Sun, HD.,Zhao, XY.,Hou, JW.,Hou, AJ.,...&Xin, WJ.(2002).Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A.LIFE SCIENCES,70(16),1889-1899.
MLA Wei, TT,et al."Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A".LIFE SCIENCES 70.16(2002):1889-1899.
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