Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A
Wei, TT; Sun, HD; Zhao, XY; Hou, JW; Hou, AJ; Zhao, QS; Xin, WJ
2002-03-08
Source PublicationLIFE SCIENCES
Volume70Issue:16Pages:1889-1899
AbstractPistafolia A is a novel gallotannin isolated from the leaf extract of Pastacia weinmannifolia. In the present investigation, the ability of Pistafolia A to scavenge reactive oxygen species including hydroxyl radicals and superoxide anion was treasured by ESR spin trapping technique. The inhibition effect on iron-induced lipid peroxidaiton in liposomes was studied. The protective effects of Pistafolia A against oxidative neuronal cell damage and apoptosis induced by peroxynitrite were also assessed. The results showed that Pistafolia A could scavenge both hydroxyl radicals and superoxide anion dose-dependently and inhibit lipid peroxidation effectively. In cerebellar granule cells pretreated with Pistafolia A, peroxynitrite-induced oxidative neuronal damage and apoptosis were prevented markedly. The antioxidant capacity of Pistafolia A was much more potent then that of the water-soluble analog of vitamin E, Trolox. The results suggested that Pistafolia A might be used as an effective natural antioxidant for the prevention and cure of neuronal diseases associated with the production of peroxynitrite and related reactive oxygen species. (C) 2002 Elsevier Science Inc. All rights reserved.
KeywordPistafolia a Gallotannin Free Radical Cerebellar Granule Cell Oxidative Stress Apoptosis
Subject AreaMedicine, Research & Experimental ; Pharmacology & Pharmacy
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine ; Pharmacology & Pharmacy
WOS SubjectMedicine, Research & Experimental ; Pharmacology & Pharmacy
WOS IDWOS:000174822100005
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/14607
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Biophys, Dept Mol & Cellular Biophys, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Wei, TT,Sun, HD,Zhao, XY,et al. Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A[J]. LIFE SCIENCES,2002,70(16):1889-1899.
APA Wei, TT.,Sun, HD.,Zhao, XY.,Hou, JW.,Hou, AJ.,...&Xin, WJ.(2002).Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A.LIFE SCIENCES,70(16),1889-1899.
MLA Wei, TT,et al."Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, Pistafolia A".LIFE SCIENCES 70.16(2002):1889-1899.
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