| Structure and Cytotoxicity of Diterpeinoids from Isodon adenolomus | |
Zhao, Wei1,2; Pu, Jian-Xin1 ; Du, Xue1; Su, Jia1; Li, Xiao-Nian1; Yang, Jian-Hong1; Xue, Yong-Bo1,2; Li, Yan1; Xiao, Wei-Lie1; Sun, Han-Dong1
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| 通讯作者 | Pu, JX (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China |
| 2011-05-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 74期号:5页码:1213-1220 |
| 摘要 | Twelve new diterpenoids, isoadenolins A-L (1-12), and 24 known ones were isolated from the aerial parts of Isodon adenolomus. Their structures were identified using spectroscopic data, and the absolute configurations of 1 and 14 were determined by single-crystal X-ray diffraction. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Compounds 9, 13-16, and 21 showed significant inhibitory effects on all five cells, with IC(50) values in the range 0.7-9.7 mu M. |
| 关键词 | Rubescens Var.-taihangensis Anti-bacterial Diterpenoids Ent-kaurene Diterpenoids Lasiocarpus Hayata Kudo Kaurane Diterpenoids Xerophilus Constituents Terpenoids |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np200140j |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000291127900044 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/14487 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Wei,Pu, Jian-Xin,Du, Xue,et al. Structure and Cytotoxicity of Diterpeinoids from Isodon adenolomus[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(5):1213-1220. |
| APA | Zhao, Wei.,Pu, Jian-Xin.,Du, Xue.,Su, Jia.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2011).Structure and Cytotoxicity of Diterpeinoids from Isodon adenolomus.JOURNAL OF NATURAL PRODUCTS,74(5),1213-1220. |
| MLA | Zhao, Wei,et al."Structure and Cytotoxicity of Diterpeinoids from Isodon adenolomus".JOURNAL OF NATURAL PRODUCTS 74.5(2011):1213-1220. |
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