Structure and Cytotoxicity of Diterpeinoids from Isodon adenolomus
Zhao, Wei1,2; Pu, Jian-Xin1; Du, Xue1; Su, Jia1; Li, Xiao-Nian1; Yang, Jian-Hong1; Xue, Yong-Bo1,2; Li, Yan1; Xiao, Wei-Lie1; Sun, Han-Dong1
2011-05-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号74期号:5页码:1213-1220
摘要Twelve new diterpenoids, isoadenolins A-L (1-12), and 24 known ones were isolated from the aerial parts of Isodon adenolomus. Their structures were identified using spectroscopic data, and the absolute configurations of 1 and 14 were determined by single-crystal X-ray diffraction. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Compounds 9, 13-16, and 21 showed significant inhibitory effects on all five cells, with IC(50) values in the range 0.7-9.7 mu M.
关键词Rubescens Var.-taihangensis Anti-bacterial Diterpenoids Ent-kaurene Diterpenoids Lasiocarpus Hayata Kudo Kaurane Diterpenoids Xerophilus Constituents Terpenoids
资助信息NSFC-Joint Foundation of Yunnan Province[U0832602]; major direction projection foundation of CAS[2010KIBA05]; Major State Basic Research Development Program of China[2009CB522300, 2009CB940900]; Science and Technology Program of Yunnan Province[2008IF010, 2008CD162]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np200140j
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000291127900044
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14487
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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GB/T 7714
Zhao, Wei,Pu, Jian-Xin,Du, Xue,et al. Structure and Cytotoxicity of Diterpeinoids from Isodon adenolomus[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(5):1213-1220.
APA Zhao, Wei.,Pu, Jian-Xin.,Du, Xue.,Su, Jia.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2011).Structure and Cytotoxicity of Diterpeinoids from Isodon adenolomus.JOURNAL OF NATURAL PRODUCTS,74(5),1213-1220.
MLA Zhao, Wei,et al."Structure and Cytotoxicity of Diterpeinoids from Isodon adenolomus".JOURNAL OF NATURAL PRODUCTS 74.5(2011):1213-1220.
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