| Abietane Diterpenoids and a Lignan from Pinus yunnanensis | |
Feng, Tao1,2; Cai, Xiang-Hai1 ; Tan, Qin-Gang1; Luo, Xiao-Dong1
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| 2010-06-01 | |
| 发表期刊 | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
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| ISSN | 0932-0776 |
| 卷号 | 65期号:6页码:765-769 |
| 摘要 | Two new abietane diterpene acids, pinyunins A (1) and B (2), a new lignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(2,3-dihydroxyphenyl)propane-1,3-diol (3), and eight known diterpenoids (4-11) were isolated from the bark of Pinus yunnanensis Franch. Their structures were elucidated by spectroscopic methods. Compounds 1-3 exhibited high inhibitions on Cox-2 (> 80%) and low inhibitions on Cox-1 (< 50 %), showing the trend of selective inhibition of Cox-2, while the positive controls NS-398 (Cox-2) and SC-560 (Cox-1) gave inhibitions of 97.09% and 61.30%, respectively. Compounds 1-11 were evaluated for their cytotoxicity against five human cancer cell lines with Cisplatin as a positive control. |
| 关键词 | Pinus Yunnanensis Pinaceae Diterpenoids Lignan Anti-inflammatory Activity Cytotoxicity |
| 学科领域 | Chemistry, Inorganic & Nuclear ; Chemistry, Organic |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000280568100014 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/14405 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Tao,Cai, Xiang-Hai,Tan, Qin-Gang,et al. Abietane Diterpenoids and a Lignan from Pinus yunnanensis[J]. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES,2010,65(6):765-769. |
| APA | Feng, Tao,Cai, Xiang-Hai,Tan, Qin-Gang,&Luo, Xiao-Dong.(2010).Abietane Diterpenoids and a Lignan from Pinus yunnanensis.ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES,65(6),765-769. |
| MLA | Feng, Tao,et al."Abietane Diterpenoids and a Lignan from Pinus yunnanensis".ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 65.6(2010):765-769. |
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