Abietane Diterpenoids and a Lignan from Pinus yunnanensis
Feng, Tao1,2; Cai, Xiang-Hai1; Tan, Qin-Gang1; Luo, Xiao-Dong1
2010-06-01
发表期刊ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
ISSN0932-0776
卷号65期号:6页码:765-769
摘要Two new abietane diterpene acids, pinyunins A (1) and B (2), a new lignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(2,3-dihydroxyphenyl)propane-1,3-diol (3), and eight known diterpenoids (4-11) were isolated from the bark of Pinus yunnanensis Franch. Their structures were elucidated by spectroscopic methods. Compounds 1-3 exhibited high inhibitions on Cox-2 (> 80%) and low inhibitions on Cox-1 (< 50 %), showing the trend of selective inhibition of Cox-2, while the positive controls NS-398 (Cox-2) and SC-560 (Cox-1) gave inhibitions of 97.09% and 61.30%, respectively. Compounds 1-11 were evaluated for their cytotoxicity against five human cancer cell lines with Cisplatin as a positive control.
关键词Pinus Yunnanensis Pinaceae Diterpenoids Lignan Anti-inflammatory Activity Cytotoxicity
学科领域Chemistry, Inorganic & Nuclear ; Chemistry, Organic
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Inorganic & Nuclear ; Chemistry, Organic
WOS记录号WOS:000280568100014
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14405
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Feng, Tao,Cai, Xiang-Hai,Tan, Qin-Gang,et al. Abietane Diterpenoids and a Lignan from Pinus yunnanensis[J]. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES,2010,65(6):765-769.
APA Feng, Tao,Cai, Xiang-Hai,Tan, Qin-Gang,&Luo, Xiao-Dong.(2010).Abietane Diterpenoids and a Lignan from Pinus yunnanensis.ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES,65(6),765-769.
MLA Feng, Tao,et al."Abietane Diterpenoids and a Lignan from Pinus yunnanensis".ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 65.6(2010):765-769.
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