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题名: Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity
作者: Zhang, Ling1, 3; Shen, Yu2; Zhu, Hua-Jie1; Wang, Fei1, 4; Leng, Ying2; Liu, Ji-Kai1
刊名: JOURNAL OF ANTIBIOTICS
关键词: basidiomycete ; catathelasmols A-E ; Catathelasma imperiale ; pentanol derivatives ; 11 beta-hydroxysteroid dehydrogenases
英文摘要: Five new secondary metabolites derived from pentanol, namely catathelasmols A-E (1-5), were isolated from the fruiting bodies of the basidiomycete Catathelasma imperiale. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were determined by computational chemistry. Compounds 3, 4 and 5 showed inhibitory activities against two isozymes of 11 beta-hydroxysteroid clehydrogenases (11 beta-HSD1 and 11 beta-HSD2), with IC(50) values of 28.7-62.3 mu g ml(-1) (human 11 beta-HSD1), 30.4-149.2 mu g ml(-1) (mouse 11 beta-HSD1), 5.1-177 mu g ml(-1) (human 11 beta-HSD2) and 32.3-129 mu g ml(-1) (mouse 11 beta-HSD2), which catalyze the interconversion of cortisol and cortisone. The Journal of Antibiotics (2009) 62, 239-242; doi:10.1038/ja.2009.17; published online 27 March 2009
出版日期: 2009-05-01
卷号: 62, 期号:5, 页码:239-242
DOI标识: 10.1038/ja.2009.17
语种: 英语
ISSN号: 0021-8820
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13691
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
4.BioBioPha Co Ltd, Kunming, Peoples R China

Recommended Citation:
Zhang, L; Shen, Y; Zhu, HJ; Wang, F; Leng, Y; Liu, JK.Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity,JOURNAL OF ANTIBIOTICS,2009,62(5):239-242
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