Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity
Zhang, Ling1,3; Shen, Yu2; Zhu, Hua-Jie1; Wang, Fei1,4; Leng, Ying2; Liu, Ji-Kai1
2009-05-01
发表期刊JOURNAL OF ANTIBIOTICS
ISSN0021-8820
卷号62期号:5页码:239-242
摘要Five new secondary metabolites derived from pentanol, namely catathelasmols A-E (1-5), were isolated from the fruiting bodies of the basidiomycete Catathelasma imperiale. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were determined by computational chemistry. Compounds 3, 4 and 5 showed inhibitory activities against two isozymes of 11 beta-hydroxysteroid clehydrogenases (11 beta-HSD1 and 11 beta-HSD2), with IC(50) values of 28.7-62.3 mu g ml(-1) (human 11 beta-HSD1), 30.4-149.2 mu g ml(-1) (mouse 11 beta-HSD1), 5.1-177 mu g ml(-1) (human 11 beta-HSD2) and 32.3-129 mu g ml(-1) (mouse 11 beta-HSD2), which catalyze the interconversion of cortisol and cortisone. The Journal of Antibiotics (2009) 62, 239-242; doi:10.1038/ja.2009.17; published online 27 March 2009
关键词Basidiomycete Catathelasmols A-e Catathelasma Imperiale Pentanol Derivatives 11 Beta-hydroxysteroid Dehydrogenases
学科领域Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
DOI10.1038/ja.2009.17
收录类别SCI ; IC
语种英语
WOS研究方向Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
WOS类目Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
WOS记录号WOS:000266798700002
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13691
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
4.BioBioPha Co Ltd, Kunming, Peoples R China
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Zhang, Ling,Shen, Yu,Zhu, Hua-Jie,et al. Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity[J]. JOURNAL OF ANTIBIOTICS,2009,62(5):239-242.
APA Zhang, Ling,Shen, Yu,Zhu, Hua-Jie,Wang, Fei,Leng, Ying,&Liu, Ji-Kai.(2009).Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity.JOURNAL OF ANTIBIOTICS,62(5),239-242.
MLA Zhang, Ling,et al."Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity".JOURNAL OF ANTIBIOTICS 62.5(2009):239-242.
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