| Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation | |
Qing, C; Liu, MH; Yangl, WM; Zhang, YL; Wang, L ; Liu, JK
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| 2004-09-01 | |
| 发表期刊 | PLANTA MEDICA
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| ISSN | 0032-0943 |
| 卷号 | 70期号:9页码:792-796 |
| 摘要 | The effect of albaconol on the growth of human tumor cell, DNA topoisomerase (topo)-mediated DNA cleavage and direct DNA breakage was investigated. Albaconol inhibited significantly the growth of the human tumor cell lines K562, A549, BGC-823 and Bcap-37, the IC50 values were 7.99+/-0.4, 3.17+/-0.89, 4.18+/-0.14 and 7.45+/-2.5 muM, respectively. Albaconol stabilized and increased the topo II-mediated DNA cleavable complex and inhibited the religation activity of topo II in a dose-dependent manner, but it failed to affect the activity of topo I. Albaconol directly broke pBR322 DNA at high concentrations, but there was no effect on the macromolecule of K562 cells. These results strongly suggest that albaconol targeted specifically to DNA topo II and that this is one of the mechanisms of its antitumor action; the direct action of albaconol on DNA may partly contribute to its antitumor activity at high concentrations. |
| 关键词 | Albaconol Albatrellaceae Albatrellus Confluens Antitumor Activity Topoisomerase |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1055/s-2004-827224 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224440700003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/13613 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qing, C,Liu, MH,Yangl, WM,et al. Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation[J]. PLANTA MEDICA,2004,70(9):792-796. |
| APA | Qing, C,Liu, MH,Yangl, WM,Zhang, YL,Wang, L,&Liu, JK.(2004).Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation.PLANTA MEDICA,70(9),792-796. |
| MLA | Qing, C,et al."Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation".PLANTA MEDICA 70.9(2004):792-796. |
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