Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation
Qing, C; Liu, MH; Yangl, WM; Zhang, YL; Wang, L; Liu, JK
2004-09-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号70期号:9页码:792-796
摘要The effect of albaconol on the growth of human tumor cell, DNA topoisomerase (topo)-mediated DNA cleavage and direct DNA breakage was investigated. Albaconol inhibited significantly the growth of the human tumor cell lines K562, A549, BGC-823 and Bcap-37, the IC50 values were 7.99+/-0.4, 3.17+/-0.89, 4.18+/-0.14 and 7.45+/-2.5 muM, respectively. Albaconol stabilized and increased the topo II-mediated DNA cleavable complex and inhibited the religation activity of topo II in a dose-dependent manner, but it failed to affect the activity of topo I. Albaconol directly broke pBR322 DNA at high concentrations, but there was no effect on the macromolecule of K562 cells. These results strongly suggest that albaconol targeted specifically to DNA topo II and that this is one of the mechanisms of its antitumor action; the direct action of albaconol on DNA may partly contribute to its antitumor activity at high concentrations.
关键词Albaconol Albatrellaceae Albatrellus Confluens Antitumor Activity Topoisomerase
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-2004-827224
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000224440700003
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13613
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming, Peoples R China
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Qing, C,Liu, MH,Yangl, WM,et al. Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation[J]. PLANTA MEDICA,2004,70(9):792-796.
APA Qing, C,Liu, MH,Yangl, WM,Zhang, YL,Wang, L,&Liu, JK.(2004).Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation.PLANTA MEDICA,70(9),792-796.
MLA Qing, C,et al."Effects of albaconol from the basidiomycete Albatrellus confluens on DNA topoisomerase II-mediated DNA cleavage and relaxation".PLANTA MEDICA 70.9(2004):792-796.
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