Cytotoxic Triterpenoids from Azadirachta indica

doi:10.1055/s-0030-1271197

	Cytotoxic Triterpenoids from Azadirachta indica
	Chen, JinXiong 2; Chen, JianChao ; Sun, Yun 2; Yan, YuXin 2; Kong, LingMei 2; Li, Yan; Qiu, MingHua1
通讯作者	Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, 132 LanHei Rd, Kunming 650204, Yunnan, Peoples R China
	2011-11-01
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	77 期号:16 页码:1844-1847
摘要	Two new tirucallane triterpenoids, 24,25-epoxy-3 beta-hydroxy-20-oxo- 7-tirucallene (1) and 22,23; 24,25-diepoxy-3 beta-hydroxy-7-tirucallene (2), and a new tetranortriterpenoid, 4 alpha-hydroperoxy- 6-O-acetylnimbandiol (3), along with eight known compounds, were isolated from the branches and leaves of Azadirachta indica. Their structures were elucidated through spectroscopic and chemical methods. The cytotoxic assay showed that the abundant constituent nimbolide (8) had obvious cytotoxic activities against HL-60, SMMC7721, A549, MCF-7, and SW-480 cell lines, with IC(50) values of 0.8 +/- 0.1, 2.2 +/- 0.2, 1.9 +/- 1.3, 4.5 +/- 1.1, and 2.3 +/- 0.1 mu M, respectively.
关键词	Meliaceae Azadirachta Indica Tirucallane Triterpenoid Tetranortriterpenoid Cytotoxicity
学科领域	Plant Sciences ; Pharmacology & Pharmacy
DOI	10.1055/s-0030-1271197
收录类别	SCI
语种	英语
WOS记录号	WOS:000296725500015
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/13569
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Chen, JinXiong,Chen, JianChao,Sun, Yun,et al. Cytotoxic Triterpenoids from Azadirachta indica[J]. PLANTA MEDICA,2011,77(16):1844-1847.
APA	Chen, JinXiong.,Chen, JianChao.,Sun, Yun.,Yan, YuXin.,Kong, LingMei.,...&Qiu, MingHua.(2011).Cytotoxic Triterpenoids from Azadirachta indica.PLANTA MEDICA,77(16),1844-1847.
MLA	Chen, JinXiong,et al."Cytotoxic Triterpenoids from Azadirachta indica".PLANTA MEDICA 77.16(2011):1844-1847.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
PLANTA MEDICA77 1844（8011KB）			开放获取	--	浏览下载