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题名: Cytotoxic Triterpenoids from Azadirachta indica
作者: Chen, JinXiong2; Chen, JianChao; Sun, Yun2; Yan, YuXin2; Kong, LingMei2; null(李艳); null(邱明华)1
刊名: PLANTA MEDICA
关键词: Meliaceae ; Azadirachta indica ; tirucallane triterpenoid ; tetranortriterpenoid ; cytotoxicity
英文摘要: Two new tirucallane triterpenoids, 24,25-epoxy-3 beta-hydroxy-20-oxo- 7-tirucallene (1) and 22,23; 24,25-diepoxy-3 beta-hydroxy-7-tirucallene (2), and a new tetranortriterpenoid, 4 alpha-hydroperoxy- 6-O-acetylnimbandiol (3), along with eight known compounds, were isolated from the branches and leaves of Azadirachta indica. Their structures were elucidated through spectroscopic and chemical methods. The cytotoxic assay showed that the abundant constituent nimbolide (8) had obvious cytotoxic activities against HL-60, SMMC7721, A549, MCF-7, and SW-480 cell lines, with IC(50) values of 0.8 +/- 0.1, 2.2 +/- 0.2, 1.9 +/- 1.3, 4.5 +/- 1.1, and 2.3 +/- 0.1 mu M, respectively.
出版日期: 2011-11-01
卷号: 77, 期号:16, 页码:1844-1847
DOI标识: 10.1055/s-0030-1271197
语种: 英语
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13569
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Chen, JX; Chen, JC; Sun, Y; Yan, YX; Kong, LM; Li, Y; Qiu, MH.Cytotoxic Triterpenoids from Azadirachta indica,PLANTA MEDICA,2011,77(16):1844-1847
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