Cytotoxic Triterpenoids from Azadirachta indica
Chen, JinXiong2; Chen, JianChao; Sun, Yun2; Yan, YuXin2; Kong, LingMei2; Li, Yan; Qiu, MingHua1
2011-11-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号77期号:16页码:1844-1847
摘要Two new tirucallane triterpenoids, 24,25-epoxy-3 beta-hydroxy-20-oxo- 7-tirucallene (1) and 22,23; 24,25-diepoxy-3 beta-hydroxy-7-tirucallene (2), and a new tetranortriterpenoid, 4 alpha-hydroperoxy- 6-O-acetylnimbandiol (3), along with eight known compounds, were isolated from the branches and leaves of Azadirachta indica. Their structures were elucidated through spectroscopic and chemical methods. The cytotoxic assay showed that the abundant constituent nimbolide (8) had obvious cytotoxic activities against HL-60, SMMC7721, A549, MCF-7, and SW-480 cell lines, with IC(50) values of 0.8 +/- 0.1, 2.2 +/- 0.2, 1.9 +/- 1.3, 4.5 +/- 1.1, and 2.3 +/- 0.1 mu M, respectively.
关键词Meliaceae Azadirachta Indica Tirucallane Triterpenoid Tetranortriterpenoid Cytotoxicity
资助信息Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2008-ZZ05, P2010-ZZ14]; CAS[KSCX2-YW-G-038, KSCX2-EW-R-15, KSCX2-YW-R-194, KZCX2-XB2-15-03]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1055/s-0030-1271197
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000296725500015
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13569
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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Chen, JinXiong,Chen, JianChao,Sun, Yun,et al. Cytotoxic Triterpenoids from Azadirachta indica[J]. PLANTA MEDICA,2011,77(16):1844-1847.
APA Chen, JinXiong.,Chen, JianChao.,Sun, Yun.,Yan, YuXin.,Kong, LingMei.,...&Qiu, MingHua.(2011).Cytotoxic Triterpenoids from Azadirachta indica.PLANTA MEDICA,77(16),1844-1847.
MLA Chen, JinXiong,et al."Cytotoxic Triterpenoids from Azadirachta indica".PLANTA MEDICA 77.16(2011):1844-1847.
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