Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents of Dodonaea viscosa
Zhang, Lai-Bin1; Ji, Jun1; Lei, Chun1; Wang, He-Yao2; Zhao, Qin-Shi3; Hou, Ai-Jun1
Corresponding AuthorHou, AJ (reprint author), Fudan Univ, Sch Pharm, Dept Pharmacognosy, 826 Zhang Heng Rd, Shanghai 201203, Peoples R China, ajhou@shmu.edu.cn
2012-04-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume75Issue:4Pages:699-706
AbstractTen new isoprenylated flavonol derivatives, dodoviscins A-J (1-10), and seven known compounds (11-17) were isolated from the aerial parts of Dodonaea viscosa. Compounds 1, 2, 4, 5, 7-9, 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3-methoxyflavone (11), 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3,6-dimethoxyflavone (12), 5,7,4'-trihydroxy-3'-(4-hydroxy-3-methylbutyl)-5'-(3-methyl-2-buten-1-yl)-3,6-dinnethyoxyflavone (13), sakuranetin (14), and blumeatin (15) promoted adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells. Compounds 1, 13, and 15 also enhanced the accumulation of lipid droplets and induced upregulation of the expression of the adipocyte-specific genes aP2 and GLUT4.
KeywordMichelia Coriacea Genetic Diversity Critically Endangered Plant Issr Markers Ssr Markers Conservation Genetics Population-genetics Ssr Markers Rapd Issr Rare Island Aflp Flow Proteaceae
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np2009797
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000303220500028
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/10453
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Lai-Bin,Ji, Jun,Lei, Chun,et al. Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents of Dodonaea viscosa[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(4):699-706.
APA Zhang, Lai-Bin,Ji, Jun,Lei, Chun,Wang, He-Yao,Zhao, Qin-Shi,&Hou, Ai-Jun.(2012).Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents of Dodonaea viscosa.JOURNAL OF NATURAL PRODUCTS,75(4),699-706.
MLA Zhang, Lai-Bin,et al."Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents of Dodonaea viscosa".JOURNAL OF NATURAL PRODUCTS 75.4(2012):699-706.
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